Academic Journal
Subepithelial apoptosis in normal caecal biopsy specimens is primarily an age‐related phenomenon
| العنوان: | Subepithelial apoptosis in normal caecal biopsy specimens is primarily an age‐related phenomenon |
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| المؤلفون: | Wong, N A C S, Jenkins, R, Reid, G J |
| المصدر: | Histopathology ; volume 53, issue 4, page 426-431 ; ISSN 0309-0167 1365-2559 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2008 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Aims: To determine whether prominent subepithelial apoptosis in otherwise normal caecal endoscopic biopsy specimens has any clinical significance. Methods and results: Calculating the average number of subepithelial apoptotic bodies per intercrypt space [i.e. a subepithelial apoptotic index (SAI)] was found to reflect accurately and reproducibly the density of subepithelial apoptosis in a colonic biopsy specimen. The SAIs of 124 histologically normal caecal biopsy specimens from adult patients showed a positively skewed normal distribution without bimodality. The clinical details of patients with specimens in the top quartile of this distribution were compared with those of patients in the bottom quartile. Patients in the top quartile were found to be older and more likely to suffer with ulcerative colitis than those in the bottom quartile. However, controlling for age removed the association between SAI and ulcerative colitis. The SAIs of 144 caecal biopsy specimens (including 20 paediatric cases) showed a positive correlation with patient age. Conclusions: Subepithelial apoptosis in normal caecal biopsy specimens appears to be an age‐related phenomenon with no demonstrable clinical significance. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1111/j.1365-2559.2008.03137.x |
| الاتاحة: | http://dx.doi.org/10.1111/j.1365-2559.2008.03137.x https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1365-2559.2008.03137.x https://onlinelibrary.wiley.com/doi/pdf/10.1111/j.1365-2559.2008.03137.x |
| Rights: | http://onlinelibrary.wiley.com/termsAndConditions#vor |
| رقم الانضمام: | edsbas.1384BFE2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1111/j.1365-2559.2008.03137.x |
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