Academic Journal
Chemoenzymatic synthesis and biological evaluation of ganglioside GM3 and lyso-GM3 as potential agents for cancer therapy
| العنوان: | Chemoenzymatic synthesis and biological evaluation of ganglioside GM3 and lyso-GM3 as potential agents for cancer therapy |
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| المؤلفون: | Li, Tingshen, Wang, Xiaodan, Dong, Peijie, Yu, Peng, Zhang, Yongmin, Meng, Xin |
| المساهمون: | Tianjin University of Science and Technology (TUST), Shandong Academy of Sciences (SDAS), Institut Parisien de Chimie Moléculaire (IPCM), Chimie Moléculaire de Paris Centre (FR 2769), École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris Sciences et Lettres (PSL)-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris Sciences et Lettres (PSL)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | ISSN: 0008-6215. |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Chemoenzymatic synthesis, Ganglioside GM3, Sialylation, Tumor-Associated Carbohydrate Antigens (TACAs), [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology |
| الوصف: | International audience ; A highly efficient chemoenzymatic method for synthesizing ganglioside GM3 and lyso-GM3 was reported here. Enzymatic extension of the chemically synthesized lactosyl sphingosine using efficient one-pot multienzyme (OPME) reaction allowed glycosylation to be carried out in aqueous solutions realizing the greening of reactions. Ganglioside GM3 was synthesized through 10 steps with a total yield of 22%. Lyso-GM3 was very useful for kinds of derivatization. The anti-proliferation activity studies demonstrated that these compounds 14-16 with sphingosine exhibited more potency than the corresponding lyso-GM3 with ceramide. All ganglioside GM3 and lyso-GM3 can effectively inhibit the migration of melanoma B16-F10 cells. These chemoenzymaticlly synthesized GM3 and lyso-GM3 exhibited antitumor activities, which can provide valuable sights to search new antitumor agents for cancer therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03359520; https://hal.sorbonne-universite.fr/hal-03359520; https://hal.sorbonne-universite.fr/hal-03359520/document; https://hal.sorbonne-universite.fr/hal-03359520/file/Li%20et%20al.%20-%202021%20-%20Chemoenzymatic%20synthesis%20and%20biological%20evaluation.pdf |
| DOI: | 10.1016/j.carres.2021.108431 |
| الاتاحة: | https://hal.sorbonne-universite.fr/hal-03359520 https://hal.sorbonne-universite.fr/hal-03359520/document https://hal.sorbonne-universite.fr/hal-03359520/file/Li%20et%20al.%20-%202021%20-%20Chemoenzymatic%20synthesis%20and%20biological%20evaluation.pdf https://doi.org/10.1016/j.carres.2021.108431 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.134F541D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.carres.2021.108431 |
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