Academic Journal
Excreted/Secreted Proteins from Trypanosome Procyclic Strains
| العنوان: | Excreted/Secreted Proteins from Trypanosome Procyclic Strains |
|---|---|
| المؤلفون: | Celestine Michelle Atyame Nten, Nicolas Sommerer, Valerie Rofidal, Christophe Hirtz, Michel Rossignol, Gerard Cuny, Jean-Benoit Peltier, Anne Geiger |
| المصدر: | Journal of Biomedicine and Biotechnology, Vol 2010 (2010) |
| بيانات النشر: | Hindawi Limited |
| سنة النشر: | 2010 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Biotechnology, TP248.13-248.65, Medicine |
| الوصف: | Trypanosoma secretome was shown to be involved in parasite virulence and is suspected of interfering in parasite life-cycle steps such as establishment in the Glossina midgut, metacyclogenesis. Therefore, we attempted to identify the proteins secreted by procyclic strains of T. brucei gambiense and T. brucei brucei, responsible for human and animal trypanosomiasis, respectively. Using mass spectrometry, 427 and 483 nonredundant proteins were characterized in T. brucei brucei and T. brucei gambiense secretomes, respectively; 35% and 42% of the corresponding secretome proteins were specifically secreted by T. brucei brucei and T. brucei gambiense, respectively, while 279 proteins were common to both subspecies. The proteins were assigned to 12 functional classes. Special attention was paid to the most abundant proteases (14 families) because of their potential implication in the infection process and nutrient supply. The presence of proteins usually secreted via an exosome pathway suggests that this type of process is involved in trypanosome ESP secretion. The overall results provide leads for further research to develop novel tools for blocking trypanosome transmission. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1110-7243 1110-7251 |
| Relation: | http://dx.doi.org/10.1155/2010/212817; https://doaj.org/toc/1110-7243; https://doaj.org/toc/1110-7251; https://doaj.org/article/229ecbebdd3141188eeec1f50e7f7314 |
| DOI: | 10.1155/2010/212817 |
| الاتاحة: | https://doi.org/10.1155/2010/212817 https://doaj.org/article/229ecbebdd3141188eeec1f50e7f7314 |
| رقم الانضمام: | edsbas.13418CB1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 11107243 11107251 |
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| DOI: | 10.1155/2010/212817 |