Academic Journal
Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial.
| العنوان: | Therapeutic Value of Sentinel Lymph Node Biopsy in Patients With Melanoma: A Randomized Clinical Trial. |
|---|---|
| المؤلفون: | Multicenter Selective Lymphadenectomy Trials Study Group, Crystal, Jessica S, Thompson, John F, Hyngstrom, John, Caracò, Corrado, Zager, Jonathan S, Jahkola, Tiina, Bowles, Tawnya L, Pennacchioli, Elisabetta, Beitsch, Peter D, Hoekstra, Harald J, Moncrieff, Marc, Ingvar, Christian, van Akkooi, Alexander, Sabel, Michael S, Levine, Edward A, Agnese, Doreen, Henderson, Michael, Dummer, Reinhard, Neves, Rogerio I, Rossi, Carlo Riccardo, Kane, John M, Trocha, Steven, Wright, Frances, Byrd, David R, Matter, Maurice, Hsueh, Eddy C, MacKenzie-Ross, Alastair, Kelley, Mark, Terheyden, Patrick, Huston, Tara L, Wayne, Jeffrey D, Neuman, Heather, Smithers, B Mark, Ariyan, Charlotte E, Desai, Darius, Gershenwald, Jeffrey E, Schneebaum, Shlomo, Gesierich, Anja, Jacobs, Lisa K, Lewis, James M, McMasters, Kelly M, O'Donoghue, Cristina, van der Westhuizen, Andre, Sardi, Armando, Barth, Richard, Barone, Robert, McKinnon, J Greg, Slingluff, Craig L, Farma, Jeffrey M, Schultz, Erwin, Scheri, Randall P, Vidal-Sicart, Sergi, Molina, Manuel, Testori, Alessandro A E, Foshag, Lee, Van Kreuningen, Lisa, Wang, He-Jing, Sim, Myung-Shin, Scolyer, Richard A, Elashoff, David E, Cochran, Alistair J, Faries, Mark B |
| المصدر: | Articles, Abstracts, and Reports |
| بيانات النشر: | Providence St. Joseph Health Digital Commons |
| سنة النشر: | 2022 |
| المجموعة: | Providence St. Joseph Health Digital Commons |
| مصطلحات موضوعية: | california, sjci, jwci, Female, Humans, Lymph Node Excision, Lymphatic Metastasis, Male, Melanoma, Prognosis, Sentinel Lymph Node Biopsy, Skin Neoplasms, Oncology, Surgery |
| الوصف: | Importance: Sentinel lymph node (SLN) biopsy is a standard staging procedure for cutaneous melanoma. Regional disease control is a clinically important therapeutic goal of surgical intervention, including nodal surgery. Objective: To determine how frequently SLN biopsy without completion lymph node dissection (CLND) results in long-term regional nodal disease control in patients with SLN metastases. Design, Setting, and Participants: The second Multicenter Selective Lymphadenectomy Trial (MSLT-II), a prospective multicenter randomized clinical trial, randomized participants with SLN metastases to either CLND or nodal observation. The current analysis examines observation patients with regard to regional nodal recurrence. Trial patients were aged 18 to 75 years with melanoma metastatic to SLN(s). Data were collected from December 2004 to April 2019, and data were analyzed from July 2020 to January 2022. Interventions: Nodal observation with ultrasonography rather than CLND. Main Outcomes and Measures: In-basin nodal recurrence. Results: Of 823 included patients, 479 (58.2%) were male, and the mean (SD) age was 52.8 (13.8) years. Among 855 observed basins, at 10 years, 80.2% (actuarial; 95% CI, 77-83) of basins were free of nodal recurrence. By univariable analysis, freedom from regional nodal recurrence was associated with age younger than 50 years (hazard ratio [HR], 0.49; 95% CI, 0.34-0.70; P < .001), nonulcerated melanoma (HR, 0.36; 95% CI, 0.36-0.49; P < .001), thinner primary melanoma (less than 1.5 mm; HR, 0.46; 95% CI, 0.27-0.78; P = .004), axillary basin (HR, 0.61; 95% CI, 0.44-0.86; P = .005), fewer positive SLNs (1 vs 3 or more; HR, 0.32; 95% CI, 0.14-0.75; P = .008), and SLN tumor burden (measured by diameter less than 1 mm [HR, 0.39; 95% CI, 0.26-0.60; P = .001] or less than 5% area [HR, 0.36; 95% CI, 0.24-0.54; P < .001]). By multivariable analysis, younger age (HR, 0.57; 95% CI, 0.39-0.84; P = .004), thinner primary melanoma (HR, 0.40; 95% CI, 0.22-0.70; P = .002), axillary basin (HR, 0.55; ... |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| Relation: | https://digitalcommons.psjhealth.org/publications/6414; https://pubmed.ncbi.nlm.nih.gov/35921122 |
| الاتاحة: | https://digitalcommons.psjhealth.org/publications/6414 https://pubmed.ncbi.nlm.nih.gov/35921122 |
| رقم الانضمام: | edsbas.13164676 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |