Academic Journal
Objective sputum colour assessment and clinical outcomes in bronchiectasis: data from the European Bronchiectasis Registry EMBARC
| العنوان: | Objective sputum colour assessment and clinical outcomes in bronchiectasis: data from the European Bronchiectasis Registry EMBARC |
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| المؤلفون: | Aliberti, S., Ringshausen, F., Dhar, R., Haworth, C., Loebinger, M., Dimakou, K., Crichton, M., De Soyza, A., Vendrell, M., Burgel, P., McDonnell, M., Skrgat, S., Noi, A., Munteanu, O.I. |
| المصدر: | European Respiratory Journal 1-14 |
| سنة النشر: | 2024 |
| مصطلحات موضوعية: | adult, bronchiectasis, Calcium Phosphates, color, Humans, Prospective Studies, quality of life, Registries, sputum |
| الوصف: | BACKGROUND: A validated 4-point sputum colour chart can be used to objectively evaluate the levels of airway inflammation in bronchiectasis patients. In the European Bronchiectasis Registry EMBARC, we tested whether sputum colour would be associated with disease severity and clinical outcomes. METHODS: We used a prospective, observational registry of adults with bronchiectasis conducted in 31 countries. Patients who did not produce spontaneous sputum were excluded from the analysis. The Murray sputum colour chart was used at baseline and at follow-up visits. Key outcomes were frequency of exacerbations, hospitalisations for severe exacerbations and mortality during up to 5-year follow-up. RESULTS: 13thinsp;484 patients were included in the analysis. More purulent sputum was associated with lower forced expiratory volume in 1 s FEV1, worse quality of life, greater bacterial infection and a higher bronchiectasis severity index. Sputum colour was strongly associated with the risk of future exacerbations during follow-up. Compared to patients with mucoid sputum reference group, patients with mucopurulent sputum experienced significantly more exacerbations incident rate ratio IRR 1.29, 95% CI 1.22-1.38; p0.0001, while the rates were even higher for patients with purulent IRR 1.55, 95% CI 1.44-1.67; p0.0001 and severely purulent sputum IRR 1.91, 95% CI 1.52-2.39; p0.0001. Hospitalisations for severe exacerbations were also associated with increasing sputum colour with rate ratios, compared to patients with mucoid sputum, of 1.41 95% CI 1.29-1.56; p0.0001, 1.98 95% CI 1.77-2.21; p0.0001 and 3.05 95% CI 2.25-4.14; p0.0001 for mucopurulent, purulent and severely purulent sputum, respectively. Mortality was significantly increased with increasing sputum purulence, hazard ratio 1.12 95% CI 1.01-1.24; p=0.027, for each increment in sputum purulence. CONCLUSION: Sputum colour is a simple marker of disease severity and future risk of exacerbations, severe exacerbations and mortality in patients with bronchiectasis.nbsp |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 09031936 |
| Relation: | https://ibn.idsi.md/vizualizare_articol/202945; urn:issn:09031936 |
| DOI: | 10.1183/13993003.01554-2023 |
| الاتاحة: | https://ibn.idsi.md/vizualizare_articol/202945 https://doi.org/10.1183/13993003.01554-2023 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.130B60FB |
| قاعدة البيانات: | BASE |
| تدمد: | 09031936 |
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| DOI: | 10.1183/13993003.01554-2023 |