Academic Journal
Renal graft function in transplanted patients correlates with CD45RC T cell phenotypic signature
| العنوان: | Renal graft function in transplanted patients correlates with CD45RC T cell phenotypic signature |
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| المؤلفون: | Bézie, Séverine, Sérazin, Céline, Autrusseau, Elodie, Vimond, Nadège, Giral, Magali, Anegon, Ignacio, Guillonneau, Carole |
| المساهمون: | Centre de Recherche en Transplantation et Immunologie - Center for Research in Transplantation and Translational Immunology (U1064 Inserm - CR2TI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut de Transplantation et de Recherche en Transplantation CHU Nantes (ITERT), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), This work was partially funded by the Labex IGO program supported by the National Research Agency via the investment of the future program ANR-11-LABX-0016-01. This work was supported by an Etoiles Montantes from Pays de la Loire to C.G. This work was also realized in the context of the support provided by the Fondation Progreffe. This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No 825392. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript., ANR-11-LABX-0016,IGO,Immunothérapies Grand Ouest(2011) |
| المصدر: | ISSN: 1932-6203. |
| بيانات النشر: | HAL CCSD Public Library of Science |
| سنة النشر: | 2024 |
| المجموعة: | Université de Nantes: HAL-UNIV-NANTES |
| مصطلحات موضوعية: | MESH: Biomarkers, MESH: CD8-Positive T-Lymphocytes, MESH: Graft Rejection, MESH: HLA-DR Antigens, MESH: Humans, MESH: Leukocyte Common Antigens / metabolism, MESH: Protein Tyrosine Phosphatases, MESH: Reproducibility of Results, [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; Biomarkers that could predict the evolution of the graft in transplanted patients and that could allow to adapt the care of the patients would be an invaluable tool. Additionally, certain biomarkers can be target of treatments and help to stratify patients. Potential effective biomarkers have been identified but still need to be confirmed. CD45RC, one of the splicing variants of the CD45 molecule, a tyrosine phosphatase that is critical in negatively or positively regulating the TCR and the BCR signaling, is one marker already described. The frequency of CD8 + T cells expressing high levels of CD45RC before transplantation is increased in patients with an increased risk of acute rejection. However, single biomarkers have limited predictive reliability and the correlation of the expression levels of CD45RC with other cell markers was not reported. In this study, we performed a fluorescent-based high dimensional immunophenotyping of T cells on a cohort of 69 kidney transplant patients either with stable graft function or having experienced acute transplant rejection during the first year after transplantation or at the time of rejection. We identified combinations of markers and cell subsets associated with activation/inflammation or Tregs/tolerance (HLA-DR, PD-1, IFNγ, CD28) as significant biomarkers associated to transplant outcome, and showed the importance of cell segregation based on the CD45RC marker to identify the signature of a stable graft function. Our study highlights potential reliable biomarkers in transplantation to predict and/or monitor easily graft-directed immune responses and adapt immunosuppression treatments to mitigate adverse effects. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | info:eu-repo/semantics/altIdentifier/pmid/38512889; inserm-04534487; https://inserm.hal.science/inserm-04534487; https://inserm.hal.science/inserm-04534487/document; https://inserm.hal.science/inserm-04534487/file/journal.pone.0300032.pdf; PUBMED: 38512889; PUBMEDCENTRAL: PMC10956768 |
| DOI: | 10.1371/journal.pone.0300032 |
| الاتاحة: | https://inserm.hal.science/inserm-04534487 https://inserm.hal.science/inserm-04534487/document https://inserm.hal.science/inserm-04534487/file/journal.pone.0300032.pdf https://doi.org/10.1371/journal.pone.0300032 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.12BC6061 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0300032 |
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