Academic Journal
Gut microbiome composition and intestinal immunity in antiphospholipid syndrome patients versus healthy controls
| العنوان: | Gut microbiome composition and intestinal immunity in antiphospholipid syndrome patients versus healthy controls |
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| المؤلفون: | Jansen, Valérie LBI, Davids, Mark, van Mourik, Dagmar JM, Levels, Johannes HM, Coppens, Michiel, Middeldorp, Saskia, Nieuwdorp, Max, van Mens, Thijs E |
| المساهمون: | Amsterdam University Medical Centers, ZONMW-VICI, Dutch Heart Foundation, Out of the Box Grant of Amsterdam Reproduction & Development |
| المصدر: | Lupus ; volume 33, issue 12, page 1373-1378 ; ISSN 0961-2033 1477-0962 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2024 |
| الوصف: | Introduction The gut microbiome is recognized as a factor that could potentially contribute to the persistent antibodies of antiphospholipid syndrome (APS). Gut microbial interventions can both induce and mitigate APS in mice. In human APS patients, anti-beta-2-glycoprotein I (β2GP-1) titers correlate with antibody titers against a gut commensal protein homologous to β2GP-1. Aim To investigate the effect of the intestinal microenvironment on human APS. Methods We cross-sectionally compared intestinal microbiota composition quantified by shotgun sequencing; fecal short chain fatty acids (SCFAs), bacterial metabolites known to affect autoimmune processes; and fecal calprotectin, an intestinal inflammatory marker, in APS patients and healthy controls. Results Neither alpha nor beta diversity of the gut microbiota differed between APS patients (n = 15) and controls (n = 16) and no taxa were differentially abundant. Moreover, fecal SCFAs and fecal calprotectin, did not differ between the groups. Conclusion Gut microbiome effects on the APS phenotype are likely not driven by bacterial overabundance, SCFA production or intestinal inflammation. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/09612033241274515 |
| الاتاحة: | https://doi.org/10.1177/09612033241274515 https://journals.sagepub.com/doi/pdf/10.1177/09612033241274515 https://journals.sagepub.com/doi/full-xml/10.1177/09612033241274515 |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.128EECCB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/09612033241274515 |
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