Academic Journal
Predictors of biochemical recurrence after Retzius-sparing robot-assisted radical prostatectomy: Analysis of 359 cases with a median follow-up period of 26 months
| العنوان: | Predictors of biochemical recurrence after Retzius-sparing robot-assisted radical prostatectomy: Analysis of 359 cases with a median follow-up period of 26 months |
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| المساهمون: | Ali Abdel Raheem, Ki Don Chang, Mohammed Jayed Alenzi, Won Sik Ham, Woong Kyu Han, Young Deuk Choi, Koon Ho Rha, Rha, Koon Ho |
| بيانات النشر: | Blackwell Science Asia |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Retzius-sparing, biochemical recurrence, prostate cancer |
| الوصف: | OBJECTIVES: Our aim was to evaluate the predictors of biochemical recurrence after Retzius-sparing robot-assisted radical prostatectomy. METHODS: The study cohort consisted of 359 consecutive non-metastatic prostate cancer patients who underwent Retzius-sparing robot-assisted radical prostatectomy between November 2012 and January 2016. According to the National Comprehensive Cancer Network prostate cancer risk classification, 164 patients (45.7%) had high- or very high-risk prostate cancer. No patient received adjuvant therapy until documented biochemical recurrence. Biochemical recurrence-free survival was estimated using the Kaplan-Meier method. Univariable and multivariable Cox proportional hazards regression models were used to determine variables predictive of biochemical recurrence. RESULTS: The median follow-up period was 26 months (interquartile range 19-38 months). The overall biochemical recurrence rate was 14.8%, and the median time to biochemical recurrence was 11 months (interquartile range 6-22 months). The 3-year biochemical recurrence-free survival probability was 71.2%, 72.1%, 88.7%, 82.3% and 95.7% in very high-, high-, intermediate-, low- and very low-risk prostate cancer, respectively (log-rank, P < 0.001). On multivariable analysis, preoperative prostate-specific antigen (hazard ratio 1.03, 95% confidence interval 1.02-1.04; P < 0.0001), percentage of maximum core involvement on biopsy (hazard ratio 1.02, 95% confidence interval 1.01-1.03; P = 0.029) and clinical stage ≥T3a (hazard ratio 2.12, 95% confidence interval 1.02-4.39; P = 0.043) were predictors of biochemical recurrence, whereas pathological Gleason score ≥8 (hazard ratio 5.63, 95% confidence interval 1.62-19.61; P = 0.007) and pathological tumor volume (hazard ratio 1.08, 95% confidence interval 1.04-1.20; P < 0.001) were the main pathological predictors of biochemical recurrence. CONCLUSIONS: Retzius-sparing robot-assisted radical prostatectomy confers effective biochemical recurrence control at the mid-term follow-up ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0919-8172 1442-2042 |
| Relation: | INTERNATIONAL JOURNAL OF UROLOGY; J01169; OAK-2018-50513; https://ir.ymlib.yonsei.ac.kr/handle/22282913/167306; T201805477; INTERNATIONAL JOURNAL OF UROLOGY, Vol.25(12) : 1006-1014, 2018; 61508 |
| DOI: | 10.1111/iju.13808 |
| الاتاحة: | https://ir.ymlib.yonsei.ac.kr/handle/22282913/167306 https://doi.org/10.1111/iju.13808 https://onlinelibrary.wiley.com/doi/full/10.1111/iju.13808 |
| Rights: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ |
| رقم الانضمام: | edsbas.127FB5D |
| قاعدة البيانات: | BASE |
| تدمد: | 09198172 14422042 |
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| DOI: | 10.1111/iju.13808 |