Academic Journal
Potential role of iron in repair of inflammatory demyelinating lesions.
| العنوان: | Potential role of iron in repair of inflammatory demyelinating lesions. |
|---|---|
| المؤلفون: | Lee, Nathanael J, MD, Ha, Seung-Kwon, Sati, Pascal, Absinta, Martina, Nair, Govind, Luciano, Nicholas J, Leibovitch, Emily C, Yen, Cecil C, Rouault, Tracey A, Silva, Afonso C, Jacobson, Steven, Reich, Daniel S |
| المصدر: | Department of Medicine |
| بيانات النشر: | LVHN Scholarly Works |
| سنة النشر: | 2019 |
| المجموعة: | Lehigh Valley Health Network: LVHN Scholarly Works |
| مصطلحات موضوعية: | Adult, Aged, Animals, Callithrix, Demyelinating Diseases, Encephalomyelitis, Autoimmune, Experimental, Female, Humans, Inflammation, Iron, Macrophages, Male, Microglia, Middle Aged, Models, Neurological, Multiple Sclerosis, Receptors, Transferrin, Remyelination, Department of Medicine, Medicine and Health Sciences |
| الوصف: | Inflammatory destruction of iron-rich myelin is characteristic of multiple sclerosis (MS). Although iron is needed for oligodendrocytes to produce myelin during development, its deposition has also been linked to neurodegeneration and inflammation, including in MS. We report perivascular iron deposition in multiple sclerosis lesions that was mirrored in 72 lesions from 13 marmosets with experimental autoimmune encephalomyelitis. Iron accumulated mainly inside microglia/macrophages from 6 weeks after demyelination. Consistently, expression of transferrin receptor, the brain's main iron-influx protein, increased as lesions aged. Iron was uncorrelated with inflammation and postdated initial demyelination, suggesting that iron is not directly pathogenic. Iron homeostasis was at least partially restored in remyelinated, but not persistently demyelinated, lesions. Taken together, our results suggest that iron accumulation in the weeks after inflammatory demyelination may contribute to lesion repair rather than inflammatory demyelination per se. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| Relation: | https://scholarlyworks.lvhn.org/medicine/2943; https://pubmed.ncbi.nlm.nih.gov/31498148/ |
| الاتاحة: | https://scholarlyworks.lvhn.org/medicine/2943 https://pubmed.ncbi.nlm.nih.gov/31498148/ |
| رقم الانضمام: | edsbas.12463EF6 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |