Academic Journal
The Thiol-Disulfide Homeostasis and Coenzyme Q10 in Conjunction with Vitamin E Effect on Retinopathy Prematurity
| العنوان: | The Thiol-Disulfide Homeostasis and Coenzyme Q10 in Conjunction with Vitamin E Effect on Retinopathy Prematurity |
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| المؤلفون: | Akdoğan, Müberra, Üstündağ, Yasemin, Akdağ, Arzu, Neşelioğlu, Salim, Erel, Özcan |
| المساهمون: | Akdoğan, Müberra |
| بيانات النشر: | Bentham Science Publ Ltd |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Antioxidants, Coenzyme Q10, Retinopathy of Prematurity, Thiol, Vitamin E, FRAP |
| الوصف: | WOS:000476645600002 ; Purpose: This study was performed to determine whether one drop of topical administration of Coqun (R) (Coenzyme Q10 and Vitamin E)-a potent antioxidant-twice a day has any effect on the thiol-disulphide homeostasis-a novel oxidative stress marker in the Retinopathy Of Prematurity (ROP) disease course. Methods: This was a prospective observational study comprising 28 infants with ROP at stage 2 and higher who followed up at the paediatric intensive care unit. Ferric reducing power of plasma (FRAP), albumin, ischemia-modified albumin (IMA) and thiol disulphide homeostasis levels were studied in the infants before and two weeks after Coqun (R) treatment. Results: The mean gestational age was 27 (24-32) weeks, the mean birth weight was 1,012 +/- 326 g and the mean duration of care in an incubator was 64 +/- 23 days. FRAP levels were 0.91 +/- 0.17 mu mol/L, IMAs were 0.85 +/- 0.29, native thiols were 248 +/- 38.9 mu mol/L and total thiols were 284 +/- 39.2 mu mol/L, respectively, at the beginning of therapy. FRAP levels 0.79 +/- 0.21(p=0.006) mu mol/L, IMAs 0.73 +/- 0.36(p = 0.096), native thiols 262 +/- 42.6(p = 0.164) mu mol/L and total thiols 291 +/- 43.6(p = 0.344) mu mol/L showed no difference after two weeks of therapy. Conclusion: Thiol disulphide homeostasis levels do not change with Coqun (R) therapy during ROP course. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1874-3641 |
| Relation: | Open Ophthalmology Journal; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.2174/1874364101913010023; https://hdl.handle.net/20.500.12933/401; 13; 23; 28 |
| DOI: | 10.2174/1874364101913010023 |
| الاتاحة: | https://hdl.handle.net/20.500.12933/401 https://doi.org/10.2174/1874364101913010023 |
| Rights: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.12316A6D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 18743641 |
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| DOI: | 10.2174/1874364101913010023 |