Academic Journal
Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus
| العنوان: | Association between serum uric acid and nonalcoholic fatty liver disease in community patients with type 2 diabetes mellitus |
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| المؤلفون: | Xu, Linxin, Li, Ting, Yin, Jianhong, Lin, Gang, Xu, Yali, Ren, Yi, Wang, Yan, Yang, Jing, Chen, Liming |
| المساهمون: | National Natural Science Foundation of China, Natural Science Foundation of Tianjin, Shanxi Provincial Health and Family Planning Commission |
| المصدر: | PeerJ ; volume 7, page e7563 ; ISSN 2167-8359 |
| بيانات النشر: | PeerJ |
| سنة النشر: | 2019 |
| المجموعة: | PeerJ (E-Journal - via CrossRef) |
| الوصف: | Background To investigate whether SUA is associated with NAFLD in men and women with T2DM. Methods This cross-sectional study enrolled patients with T2DM at Shanxi High-Tech Development Zone Central Hospital (June 2011 to September 2017). Patients were stratified according to gender and presence/absence of NAFLD. Parameters associated with NAFLD were identified using multivariate stepwise linear regression and univariate/multivariate logistic regression. Results Among 597 patients (325 males) enrolled, 352 had NAFLD. SUA was higher in the NAFLD group than in the non-NAFLD group for both men and women ( P < 0.001). Multiple linear regression showed that body mass index (positively), triglycerides (positively) and estimated glomerular filtration rate (negatively) were independently related to SUA ( P < 0.001). Univariate logistic regression revealed increased odds of NAFLD for SUA tertiles 2 ( P = 0.022) and 3 ( P = 0.001) in women and tertile 3 ( P = 0.039) in men. After adjustment for multiple clinical parameters, SUA tertiles were significantly associated with NAFLD for tertile 3 in women ( P = 0.014), although there were trends toward associations for tertile 2 in women ( P = 0.074) and tertiles 2 and 3 in men ( P = 0.085 and 0.054, respectively). Conclusion SUA is not independently associated with NAFLD in men or women with T2DM after rigorous adjustment for other metabolic parameters. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.7717/peerj.7563 |
| الاتاحة: | http://dx.doi.org/10.7717/peerj.7563 https://peerj.com/articles/7563.pdf https://peerj.com/articles/7563.xml https://peerj.com/articles/7563.html |
| Rights: | https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: | edsbas.12046E86 |
| قاعدة البيانات: | BASE |
| DOI: | 10.7717/peerj.7563 |
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