Academic Journal
Ontogeny and Specificities of Mucosal and Blood Human Immunodeficiency Virus Type 1-Specific CD8 + Cytotoxic T Lymphocytes
| العنوان: | Ontogeny and Specificities of Mucosal and Blood Human Immunodeficiency Virus Type 1-Specific CD8 + Cytotoxic T Lymphocytes |
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| المؤلفون: | Musey, L., Ding, Y., Cao, J., Lee, J., Galloway, C., Yuen, A., Jerome, K. R., McElrath, M. J. |
| المصدر: | Journal of Virology ; volume 77, issue 1, page 291-300 ; ISSN 0022-538X 1098-5514 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2003 |
| الوصف: | Induction of adaptive immunity to human immunodeficiency virus type 1 (HIV-1) at the mucosal site of transmission is poorly understood but crucial in devising strategies to control and prevent infection. To gain further understanding of HIV-1-specific T-cell mucosal immunity, we established HIV-1-specific CD8 + cytotoxic T-lymphocyte (CTL) cell lines and clones from the blood, cervix, rectum, and semen of 12 HIV-1-infected individuals and compared their specificities, cytolytic function, and T-cell receptor (TCR) clonotypes. Blood and mucosal CD8 + CTL had common HIV-1 epitope specificities and major histocompatibility complex restriction patterns. Moreover, both systemic and mucosal CTL lysed targets with similar efficiency, primarily through the perforin-dependent pathway in in vitro studies. Sequence analysis of the TCRβ VDJ region revealed in some cases identical HIV-1-specific CTL clones in different compartments in the same HIV-1-infected individual. These results clearly establish that a subset of blood and mucosal HIV-1-specific CTL can have a common origin and can traffic between anatomically distinct compartments. Thus, these effectors can provide immune surveillance at the mucosa, where rapid responses are needed to contain HIV-1 infection. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/jvi.77.1.291-300.2003 |
| DOI: | 10.1128/JVI.77.1.291-300.2003 |
| الاتاحة: | http://dx.doi.org/10.1128/jvi.77.1.291-300.2003 https://journals.asm.org/doi/pdf/10.1128/JVI.77.1.291-300.2003 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.11F4C99C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/jvi.77.1.291-300.2003 |
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