Chemoenzymatic Hunsdiecker-Type Decarboxylative Bromination of Cinnamic Acids

التفاصيل البيبلوغرافية
العنوان:	Chemoenzymatic Hunsdiecker-Type Decarboxylative Bromination of Cinnamic Acids
المؤلفون:	Li, Huanhuan (author), Younes, S.H.H. (author), Chen, Shaohang (author), Duan, Peigao (author), Cui, Chengsen (author), Wever, Ron (author), Zhang, Wuyuan (author), Hollmann, F. (author)
سنة النشر:	2022
المجموعة:	Delft University of Technology: Institutional Repository
مصطلحات موضوعية:	biocatalysis, decarboxylation, Hunsdiecker reaction, unsaturated carboxylic acids, vanadium chloroperoxidase, vinyl bromides
الوصف:	In this contribution, we report chemoenzymatic bromodecarboxylation (Hunsdiecker-type) of α,ß-unsaturated carboxylic acids. The extraordinarily robust chloroperoxidase from Curvularia inaequalis (CiVCPO) generated hypobromite from H2O2 and bromide, which then spontaneously reacted with a broad range of unsaturated carboxylic acids and yielded the corresponding vinyl bromide products. Selectivity issues arising from the (here undesired) addition of water to the intermediate bromonium ion could be solved by reaction medium engineering. The vinyl bromides so obtained could be used as starting materials for a range of cross-coupling and pericyclic reactions. ; BT/Biocatalysis
نوع الوثيقة:	article in journal/newspaper
اللغة:	English
Relation:	http://www.scopus.com/inward/record.url?scp=85128216059&partnerID=8YFLogxK; ACS Catalysis--2155-5435--cca88431-0c6d-40d8-8727-04c974152c22; http://resolver.tudelft.nl/uuid:405f342d-f901-4259-ac5b-bbef8c023161; https://doi.org/10.1021/acscatal.2c00485
DOI:	10.1021/acscatal.2c00485
الاتاحة:	http://resolver.tudelft.nl/uuid:405f342d-f901-4259-ac5b-bbef8c023161 https://doi.org/10.1021/acscatal.2c00485
Rights:	© 2022 Huanhuan Li, S.H.H. Younes, Shaohang Chen, Peigao Duan, Chengsen Cui, Ron Wever, Wuyuan Zhang, F. Hollmann
رقم الانضمام:	edsbas.11DA4F45
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1021/acscatal.2c00485