Academic Journal
Generating fair, reliable, and accurate neuropsychological test norms for people with HIV in a low- or middle-income country.
| العنوان: | Generating fair, reliable, and accurate neuropsychological test norms for people with HIV in a low- or middle-income country. |
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| المؤلفون: | Gouse, H, Thomas, K G F, Masson, C J, Henry, M, Joska, J A, Cysique, L A, Ling, S, Ye, X, Liu, J, Robbins, R N |
| المصدر: | J Neurovirol ; ISSN:1538-2443 |
| بيانات النشر: | Springer |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Cross-cultural assessment, HIV-associated neurocognitive disorder, HIV-associated neurocognitive impairment, Low- and middle-income country (LMIC), Normative data, Regression-based norms |
| الوصف: | Effective neuropsychological assessment of people with HIV (PWH) in low- and middle-income countries (LMICs) is hampered by the unavailability of adequate test norms. We aimed to: (1) develop demographically-corrected (regression-based) South African (SA) normative data for an HIV appropriate neuropsychological test battery for Xhosa home-language speakers; (2) compare the utility of those norms to that of (i) internal standardization norms and (ii) US test publisher norms; and (3) determine the criterion validity of the newly-developed norms. 114 controls and 102 demographically comparable Xhosa home-language people living with HIV completed a well-establised, standard HIV neuropsychological test battery assessing seven cognitive domains. Using a common performance metric (z-score), we compared control and PWH test performance and examined the extent to which the three different normative datasets embedded demographic effects e.g., education. Using internal standardization norms, analyses detected medium-sized correlations of overall test performance with age and education. Correlations were fully corrected for by the newly-developed demographically-corrected norms. Using demographically-corrected norms, PWH performed significantly more poorly than controls in five cognitive domains, whereas using internal standardization norms and test-publisher norms, PWH performed significantly more poorly than controls in one and two domains, respectively. Demographically-corrected norms estimated 43.1% of PWH were cognitively impaired; these estimates were 22.5% using test-publisher norms and 19.6% using internal standardization norms. Demographically-corrected SA norms were more sensitive to cognitive impairment in PWH than the other sets of norms. Expansion of this regression-based method to create population-appropriate norms will benefit research and clinical practice in LMICs. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | https://doi.org/10.1007/s13365-024-01235-6; https://pubmed.ncbi.nlm.nih.gov/39738926 |
| DOI: | 10.1007/s13365-024-01235-6 |
| الاتاحة: | https://doi.org/10.1007/s13365-024-01235-6 https://pubmed.ncbi.nlm.nih.gov/39738926 |
| Rights: | © 2024. The Author(s). |
| رقم الانضمام: | edsbas.1193B18B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s13365-024-01235-6 |
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