Academic Journal
Renal imaging in 199 Dutch patients with Birt-Hogg-Dube syndrome: Screening compliance and outcome
| العنوان: | Renal imaging in 199 Dutch patients with Birt-Hogg-Dube syndrome: Screening compliance and outcome |
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| المؤلفون: | Johannesma, P.C., Beek, I. van de, Wel, T.J.W.T. van der, Reinhard, R., Rozendaal, L., Starink, T.M., Waesberghe, J.H.T.M. van, Horenblas, S., Gille, H.J.J.P., Jonker, M.A., Meijers-Heijboer, H.E.J., Postmus, P.E., Houweling, A.C., Moorselaar, J.R.A. van |
| المصدر: | PLoS ONE |
| سنة النشر: | 2019 |
| المجموعة: | Leiden Repository (Leiden University) |
| الوصف: | Birt-Hogg-Dube syndrome is associated with an increased risk for renal cell carcinoma. Surveillance is recommended, but the optimal imaging method and screening interval remain to be defined. The main aim of our study was to evaluate the outcomes of RCC surveillance to get insight in the safety of annual US in these patients. Surveillance data and medical records of 199 patients with Birt-Hogg-Dube syndrome were collected retrospectively using medical files and a questionnaire. These patients were diagnosed in two Dutch hospitals and data were collected until June 2014. A first screening for renal cell carcinoma was performed in 172/199 patients (86%). Follow-up data were available from 121 patients. The mean follow-up period per patient was 4.2 years. Of the patients known to be under surveillance, 83% was screened at least annually and 94% at least every two years. Thirty-eight renal cell carcinomas had occurred in 23 patients. The mean age at diagnosis of the first tumour was 51. Eighteen tumours were visualized by ultrasound. Nine small tumours (7-27 mm) were visible on MRI or CT and not detected using ultrasound. Our data indicate that compliance to renal screening is relatively high. Furthermore, ultrasound might be a sensitive, cheap and widely available alternative for MRI or part of the MRIs for detecting clinically relevant renal tumours in BHD patients,but the limitations should be considered carefully. Data from larger cohorts are necessary to confirm these observations. ; Pathogenesis and treatment of chronic pulmonary diseases |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | lumc-id: 84093485; https://hdl.handle.net/1887/122666 |
| DOI: | 10.1371/journal.pone.0212952 |
| الاتاحة: | https://hdl.handle.net/1887/122666 https://doi.org/10.1371/journal.pone.0212952 |
| رقم الانضمام: | edsbas.119228D7 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1371/journal.pone.0212952 |
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