التفاصيل البيبلوغرافية
| العنوان: |
Enantioselective Deaminative Alkylation of Amino Acid Derivatives with Unactivated Olefins |
| المؤلفون: |
Shang-Zheng Sun (1643362), Yue-Ming Cai (7460102), De-Liang Zhang (5855741), Jia-Bao Wang (11948464), Hong-Qing Yao (11948467), Xi-Yan Rui (11948470), Ruben Martin (1516570), Ming Shang (1367952) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biophysics, Biochemistry, Medicine, Molecular Biology, Infectious Diseases, Plant Biology, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Information Systems not elsewhere classified, useful entry point, enantioselective deaminative alkylation, de novo technology, >< sup ><, unactivated olefins herein, unactivated internal olefins, >–<, amino acid derivatives, unactivated olefins, >, amino acid, peptide derivatives, within reach, wide number, thus providing, thus offering, stage functionalization, sp <, linkages via, ligand backbone |
| الوصف: |
Herein, we report the first Ni-catalyzed enantioselective deaminative alkylation of amino acid and peptide derivatives with unactivated olefins. Key for success was the discovery of a new sterically encumbered bis(oxazoline) ligand backbone, thus offering a de novo technology for accessing enantioenriched sp 3 – sp 3 linkages via sp 3 C–N functionalization. Our protocol is distinguished by its broad scope and generality across a wide number of counterparts, even in the context of late-stage functionalization. In addition, an enantioselective deaminative remote hydroalkylation reaction of unactivated internal olefins is within reach, thus providing a useful entry point for forging enantioenriched sp 3 – sp 3 centers at remote sp 3 C–H sites. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Enantioselective_Deaminative_Alkylation_of_Amino_Acid_Derivatives_with_Unactivated_Olefins/18406579 |
| DOI: |
10.1021/jacs.1c12350.s001 |
| الاتاحة: |
https://doi.org/10.1021/jacs.1c12350.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.11533D63 |
| قاعدة البيانات: |
BASE |