Academic Journal
Immunopeptidomics for next-generation bacterial vaccine development
| العنوان: | Immunopeptidomics for next-generation bacterial vaccine development |
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| المؤلفون: | Mayer, Rupert, Impens, Francis |
| المصدر: | TRENDS IN MICROBIOLOGY ; ISSN: 0966-842X ; ISSN: 1878-4380 |
| سنة النشر: | 2021 |
| المجموعة: | Ghent University Academic Bibliography |
| مصطلحات موضوعية: | Medicine and Health Sciences, MESSENGER-RNA VACCINES, T-CELL ANTIGENS, HLA-E BINDS, MYCOBACTERIUM-TUBERCULOSIS, LISTERIA-MONOCYTOGENES, MASS-SPECTROMETRY, IMMUNE-RESPONSES, PHOSPHORYLATED PEPTIDES, GAMMA, INTERFERON |
| الوصف: | Antimicrobial resistance is an increasing global threat and alternative treatments substituting failing antibiotics are urgently needed. Vaccines are recognized as highly effective tools to mitigate antimicrobial resistance; however, the selection of bacterial antigens as vaccine candidates remains challenging. In recent years, advances in mass spectrometry-based proteomics have led to the development of so-called immunopeptidomics approaches that allow the untargeted discovery of bacterial epitopes that are presented on the surface of infected cells. Especially for intracellular bacterial pathogens, immunopeptidomics holds great promise to uncover antigens that can be encoded in viral vector- or nucleic acid-based vaccines. This review provides an overview of immunopeptidomics studies on intracellular bacterial pathogens and considers future directions and challenges in advancing towards next-generation vaccines. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| Relation: | https://biblio.ugent.be/publication/8710139; http://hdl.handle.net/1854/LU-8710139; http://dx.doi.org/10.1016/j.tim.2021.04.010; https://biblio.ugent.be/publication/8710139/file/8710143 |
| DOI: | 10.1016/j.tim.2021.04.010 |
| الاتاحة: | https://biblio.ugent.be/publication/8710139 http://hdl.handle.net/1854/LU-8710139 https://doi.org/10.1016/j.tim.2021.04.010 https://biblio.ugent.be/publication/8710139/file/8710143 |
| Rights: | Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License (CC BY-NC-ND 4.0) ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.10DF861F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.tim.2021.04.010 |
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