التفاصيل البيبلوغرافية
| العنوان: |
Specific Cellular and Humoral Immune Responses to the Neoantigen RBD of SARS-CoV-2 in Patients with Primary and Secondary Immunodeficiency and Healthy Donors |
| المؤلفون: |
Kauzar Mohamed Mohamed, Kissy Guevara-Hoyer, Carlos Jiménez García, Laura García Bravo, Adolfo Jiménez-Huete, Antonia Rodríguez de la Peña, Beatriz Mediero Valeros, Cristina Cañizares Velázquez, Esther Culebras López, Noemí Cabello, Vicente Estrada, Ángel L. Corbí, Miguel Fernández-Arquero, Alberto Ocaña, Alberto Delgado-Iribarren, Mercedes Martínez-Novillo, Estefanía Bolaños, Eduardo Anguita, Ascensión Peña, Celina Benavente, Javier David Benítez Fuentes, Pedro Pérez Segura, Silvia Sánchez-Ramón |
| المصدر: |
Biomedicines; Volume 11; Issue 4; Pages: 1042 |
| بيانات النشر: |
Multidisciplinary Digital Publishing Institute |
| سنة النشر: |
2023 |
| المجموعة: |
MDPI Open Access Publishing |
| مصطلحات موضوعية: |
primary immunodeficiencies, secondary immunodeficiencies, COVID-19, SARS-CoV-2 cellular response, SARS-CoV-2 humoral response, CVID, antibody deficiency disorders |
| الوصف: |
Patients with antibody deficiency disorders, such as primary immunodeficiency (PID) or secondary immunodeficiency (SID) to B-cell lymphoproliferative disorder (B-CLPD), are two groups vulnerable to developing the severe or chronic form of coronavirus disease caused by SARS-CoV-2 (COVID-19). The data on adaptive immune responses against SARS-CoV-2 are well described in healthy donors, but still limited in patients with antibody deficiency of a different cause. Herein, we analyzed spike-specific IFN-γ and anti-spike IgG antibody responses at 3 to 6 months after exposure to SARS-CoV-2 derived from vaccination and/or infection in two cohorts of immunodeficient patients (PID vs. SID) compared to healthy controls (HCs). Pre-vaccine anti-SARS-CoV-2 cellular responses before vaccine administration were measured in 10 PID patients. Baseline cellular responses were detectable in 4 out of 10 PID patients who had COVID-19 prior to vaccination, perceiving an increase in cellular responses after two-dose vaccination (p < 0.001). Adequate specific cellular responses were observed in 18 out of 20 (90%) PID patients, in 14 out of 20 (70%) SID patients and in 74 out of 81 (96%) HCs after vaccination (and natural infection in some cases). Specific IFN-γ response was significantly higher in HC with respect to PID (1908.5 mUI/mL vs. 1694.1 mUI/mL; p = 0.005). Whereas all SID and HC patients mounted a specific humoral immune response, only 80% of PID patients showed positive anti-SARS-CoV-2 IgG. The titer of anti-SARS-CoV-2 IgG was significantly lower in SID compared with HC patients (p = 0.040), without significant differences between PID and HC patients (p = 0.123) and between PID and SID patients (p =0.683). High proportions of PID and SID patients showed adequate specific cellular responses to receptor binding domain (RBD) neoantigen, with a divergence between the two arms of the adaptive immune response in PID and SID patients. We also focused on the correlation of protection of positive SARS-CoV-2 cellular response to ... |
| نوع الوثيقة: |
text |
| وصف الملف: |
application/pdf |
| اللغة: |
English |
| Relation: |
Immunology and Immunotherapy; https://dx.doi.org/10.3390/biomedicines11041042 |
| DOI: |
10.3390/biomedicines11041042 |
| الاتاحة: |
https://doi.org/10.3390/biomedicines11041042 |
| Rights: |
https://creativecommons.org/licenses/by/4.0/ |
| رقم الانضمام: |
edsbas.10A8756D |
| قاعدة البيانات: |
BASE |