Academic Journal
Transmission and Persistence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus among Veterinarians and Their Household Members
| العنوان: | Transmission and Persistence of Livestock-Associated Methicillin-Resistant Staphylococcus aureus among Veterinarians and Their Household Members |
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| المؤلفون: | Bosch, T., Verkade, E., van Luit, M., Landman, F., Kluytmans, J., Schouls, L. M. |
| المساهمون: | Björkroth, J. |
| المصدر: | Applied and Environmental Microbiology ; volume 81, issue 1, page 124-129 ; ISSN 0099-2240 1098-5336 |
| بيانات النشر: | American Society for Microbiology |
| سنة النشر: | 2015 |
| الوصف: | After the first isolation of livestock-associated methicillin-resistant Staphylococcus aureus (LA-MRSA) in 2003, this MRSA variant quickly became the predominant MRSA obtained from humans as part of the Dutch national MRSA surveillance. Previous studies have suggested that human-to-human transmission of LA-MRSA, compared to that of other MRSA lineages, rarely occurs. However, these reports describe the transmission of LA-MRSA based on epidemiology and limited molecular characterization of isolates, making it difficult to assess whether transmission actually occurred. In this study, we used whole-genome maps (WGMs) to identify possible transmission of LA-MRSA between humans. For this, we used LA-MRSA isolates originating from a 2-year prospective longitudinal cohort study in which livestock veterinarians and their household members were repeatedly sampled for the presence of S. aureus . A considerable degree of genotypic variation among LA-MRSA strains was observed. However, there was very limited variability between the maps of the isolates originating from the same veterinarian, indicating that each of the veterinarians persistently carried or had reacquired the same LA-MRSA strain. Comparison of WGMs revealed that LA-MRSA transmission had likely occurred within virtually every veterinarian household. Yet only a single LA-MRSA strain per household appeared to be involved in transmission. The results corroborate our previous finding that LA-MRSA is genetically diverse. Furthermore, this study shows that transmission of LA-MRSA between humans occurs and that carriage of LA-MRSA can be persistent, thus posing a potential risk for spread of this highly resistant pathogen in the community. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1128/aem.02803-14 |
| DOI: | 10.1128/AEM.02803-14 |
| الاتاحة: | http://dx.doi.org/10.1128/aem.02803-14 https://journals.asm.org/doi/pdf/10.1128/AEM.02803-14 |
| Rights: | https://journals.asm.org/non-commercial-tdm-license |
| رقم الانضمام: | edsbas.10A6ADA3 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/aem.02803-14 |
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