التفاصيل البيبلوغرافية
| العنوان: |
Nickel-Catalyzed anti -Markovnikov Hydrodifluoroalkylation of Unactivated Alkenes |
| المؤلفون: |
Li-Ming Yin (10835634), Meng-Chan Sun (11945124), Xiao-Ju Si (6287384), Dandan Yang (291423), Mao-Ping Song (1533073), Jun-Long Niu (1533061) |
| سنة النشر: |
2022 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Biochemistry, Genetics, Biotechnology, Cancer, Infectious Diseases, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, mechanistic studies indicated, even nonfluorinated substrates, difluoroalkyl radical might, commercially available cf, >- markovnikov regioselectivity, >- markovnikov hydrodifluoroalkylation, highly remote alkenes, 3 , 2 , anti <, unactivated alkenes, simple alkenes, wide range, using phsih, mild conditions, key intermediate, hydride source, efficient ni, drug molecules, catalyzed hydrodifluoroalkylation |
| الوصف: |
An efficient Ni-catalyzed hydrodifluoroalkylation of unactivated alkenes with bromodifluoroacetate by using PhSiH 3 as hydride source was developed. The transformation affords aliphatic difluorides with anti -Markovnikov regioselectivity. A wide range of highly remote alkenes, simple alkenes, drug molecules, commercially available CF 2 precursors, and even nonfluorinated substrates are competent in this reaction under mild conditions, demonstrating the practicability of the strategy. Moreover, mechanistic studies indicated that the difluoroalkyl radical might be a key intermediate to this transformation. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| Relation: |
https://figshare.com/articles/journal_contribution/Nickel-Catalyzed_i_anti_i_-Markovnikov_Hydrodifluoroalkylation_of_Unactivated_Alkenes/18857896 |
| DOI: |
10.1021/acs.orglett.1c04346.s001 |
| الاتاحة: |
https://doi.org/10.1021/acs.orglett.1c04346.s001 |
| Rights: |
CC BY-NC 4.0 |
| رقم الانضمام: |
edsbas.1029B641 |
| قاعدة البيانات: |
BASE |