Academic Journal
Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons
| العنوان: | Locus coeruleus activation during environmental novelty gates cocaine-induced long-term hyperactivity of dopamine neurons |
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| المؤلفون: | Fois, Giulia, Bosque-Cordero, Karl, Vazquez-Torres, Rafael, Miliano, Cristina, Nogues, Xavier, Jimenez-Rivera, Carlos, Caille, Stéphanie, Georges, François |
| المساهمون: | Institut des Maladies Neurodégénératives Bordeaux (IMN), Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS), Institut de Neurosciences cognitives et intégratives d'Aquitaine (INCIA), Université Bordeaux Segalen - Bordeaux 2-Université Sciences et Technologies - Bordeaux 1 (UB)-SFR Bordeaux Neurosciences-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB) |
| المصدر: | EISSN: 2589-0042 ; iScience ; https://hal.science/hal-03806295 ; iScience, 2022, 25 (4), pp.104154. ⟨10.1016/j.isci.2022.104154⟩ |
| بيانات النشر: | HAL CCSD Elsevier |
| سنة النشر: | 2022 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | [SDV]Life Sciences [q-bio] |
| الوصف: | International audience ; A key feature of the brain is the ability to handle novelty. Anything that is new will stimulate curiosity and trigger exploration. Novelty preference has been proposed to predict increased sensitivity to cocaine. Different brain circuits are activated by novelty, but three specific brain regions are critical for exploring a novel environment: the noradrenergic neurons originating from the locus coeruleus (LC), the dopaminergic neurons from the ventral tegmental area (VTA), and the hippocampus. However, how exploring a novel environment can interfere with the reward system and control cocaine impact on VTA dopamine neuron plasticity is unclear. Here, we first investigated the effects of exposure to a novel environment on the tonic electrophysiological properties of VTA dopamine neurons. Then, we explored how exposure to a novel environment controls cocaineevoked plasticity in dopamine neurons. Our findings indicate that LC controls VTA dopamine neurons under physiological conditions but also after cocaine. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| Relation: | hal-03806295; https://hal.science/hal-03806295; https://hal.science/hal-03806295/document; https://hal.science/hal-03806295/file/1-s2.0-S2589004222004242-main%281%29.pdf |
| DOI: | 10.1016/j.isci.2022.104154 |
| الاتاحة: | https://hal.science/hal-03806295 https://hal.science/hal-03806295/document https://hal.science/hal-03806295/file/1-s2.0-S2589004222004242-main%281%29.pdf https://doi.org/10.1016/j.isci.2022.104154 |
| Rights: | info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.101E19BD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.isci.2022.104154 |
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