Academic Journal
Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells
| العنوان: | Food contaminant acrylamide increases expression of Cox-2 and nitric oxide synthase in breast epithelial cells |
|---|---|
| المؤلفون: | Lyn-Cook, Lascelles E, Tareke, Eden, Word, Beverly, Starlard-Davenport, Athena, Lyn-Cook, Beverly D, Hammons, George J |
| المصدر: | Toxicology and Industrial Health ; volume 27, issue 1, page 11-18 ; ISSN 0748-2337 1477-0393 |
| بيانات النشر: | SAGE Publications |
| سنة النشر: | 2010 |
| الوصف: | Acrylamide has been discovered in foods cooked at high temperature. A potentially harmful effect of this dietary component has been suggested by data indicating its association with increased breast cancer. This study investigated the potential effects of acrylamide in nontumorigenic breast cells by assessing expression levels of inducible nitric oxide synthase (iNOS) and cycloogenase-2 (Cox-2) and NOS activity, which are known to be early molecular changes in disease formation. Treatment of cells with acrylamide increased levels of iNOS (both expression and activity) and Cox-2. Its potent metabolite, glycidamide, also induced both iNOS and Cox-2, with induction of iNOS occurring at a lower concentration. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), another food-borne carcinogen, was found to induce Cox-2 expression. Combining acrylamide with PhIP did not result in a further increase. These studies suggest that further research is needed to determine the role of carcinogens formed from cooking foods in inducing early molecular changes associated with breast cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1177/0748233710380217 |
| الاتاحة: | https://doi.org/10.1177/0748233710380217 https://journals.sagepub.com/doi/pdf/10.1177/0748233710380217 |
| Rights: | https://journals.sagepub.com/page/policies/text-and-data-mining-license |
| رقم الانضمام: | edsbas.1004B417 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1177/0748233710380217 |
|---|