Report
Study of SARS-CoV-2 Spike Protein by Surface Enhanced Raman Spectroscopy and Transmission Electron Microscopy
| العنوان: | Study of SARS-CoV-2 Spike Protein by Surface Enhanced Raman Spectroscopy and Transmission Electron Microscopy |
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| المؤلفون: | Ghalawat, Monika, Meena, Virendra Kumar, Prasad, Sharda, Poddar, Pankaj, Basu, Atanu |
| سنة النشر: | 2025 |
| المجموعة: | Condensed Matter Physics (Other) |
| مصطلحات موضوعية: | Physics - Biological Physics, Condensed Matter - Materials Science |
| الوصف: | The spike protein (SP) of SARS-CoV-2 is the major molecular target for making diagnostic tests, vaccines, and therapeutic development. We used a combination of transmission electron microscopy (TEM) and surface enhanced Raman microscopy (SERS) to study its structure. Using SERS on an aluminum substrate, we were able to detect a characteristic spectrum of SP mostly due to vibration of three aromatic amino acids producing Raman shifts at 466 cm-1, 524 cm-1, 773 cm-1, 831 cm-1, 1048 cm-1, 1308 cm-1, 1457 cm-1, and 1610 cm-1. Transmission Electron Microscopy (TEM) of the SP showed periodic 2D-lattice orientation. The findings from this study have translational values for developing surface-enhanced Raman spectroscopy (SERS) based detectors for screening and testing SARS-CoV-2 signatures in diagnostic settings and contamination tracking. Comment: 16 pages, 7 figures, 1 table including supporting information |
| نوع الوثيقة: | Working Paper |
| URL الوصول: | http://arxiv.org/abs/2501.17212 |
| رقم الانضمام: | edsarx.2501.17212 |
| قاعدة البيانات: | arXiv |
| الوصف غير متاح. |