Report
Consistent Covariance estimation for stratum imbalances under minimization method for covariate-adaptive randomization
| العنوان: | Consistent Covariance estimation for stratum imbalances under minimization method for covariate-adaptive randomization |
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| المؤلفون: | Zhao, Zixuan, Song, Yanglei, Jiang, Wenyu, Tu, Dongsheng |
| سنة النشر: | 2022 |
| المجموعة: | Statistics |
| مصطلحات موضوعية: | Statistics - Methodology |
| الوصف: | Pocock and Simon's minimization method is a popular approach for covariate-adaptive randomization in clinical trials. Valid statistical inference with data collected under the minimization method requires the knowledge of the limiting covariance matrix of within-stratum imbalances, whose existence is only recently established. In this work, we propose a bootstrap-based estimator for this limit and establish its consistency, in particular, by Le Cam's third lemma. As an application, we consider in simulation studies adjustments to existing robust tests for treatment effects with survival data by the proposed estimator. It shows that the adjusted tests achieve a size close to the nominal level, and unlike other designs, the robust tests without adjustment may have an asymptotic size inflation issue under the minimization method. Comment: 29 pages, peer reviewed version, will appear in Scandinavian Journal of Statistics |
| نوع الوثيقة: | Working Paper |
| DOI: | 10.1111/sjoe.12703 |
| URL الوصول: | http://arxiv.org/abs/2209.13117 |
| رقم الانضمام: | edsarx.2209.13117 |
| قاعدة البيانات: | arXiv |
| DOI: | 10.1111/sjoe.12703 |
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