Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood
| العنوان: | Maternal vitamin D intake during pregnancy increases gene expression of ILT3 and ILT4 in cord blood |
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| المؤلفون: | Rochat , M. K., Ege , M. J., Plabst , D., Steinle , J., Bitter , S., Braun-Fahrländer , C., Dalphin , J.-C., Riedler , J., Roponen , M., Hirvonen , M.-R., Büchele , G., Renz , H., Lauener , R., Krauss-Etschmann , S., Von Mutius , E., Renseigné , Non |
| المساهمون: | Laboratoire Chrono-environnement - CNRS - UBFC (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratoire Chrono-environnement ( LCE ), Université Bourgogne Franche-Comté ( UBFC ) -Centre National de la Recherche Scientifique ( CNRS ) -Université de Franche-Comté ( UFC ) |
| المصدر: | Clinical and Experimental Allergy Clinical and Experimental Allergy, Wiley, 2009, epub ahead of print. ⟨10.1111/j.1365-2222.2009.03428.x⟩ Clinical and Experimental Allergy, Wiley, 2009, epub ahead of print. 〈10.1111/j.1365-2222.2009.03428.x〉 |
| بيانات النشر: | HAL CCSD, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Hypersensitivity, Immediate, Male, Rural Population, Membrane Glycoproteins, Antigen-Presenting Cells, Gene Expression, Receptors, Cell Surface, Fetal Blood, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, Europe, Pregnancy, Risk Factors, Dietary Supplements, Humans, Female, Prospective Studies, RNA, Messenger, Receptors, Immunologic, Vitamin D, Child, [ SDV.MHEP.PSR ] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract |
| الوصف: | International audience; Summary Background Recent studies indicate that prenatal vitamin D intake may protect against the development of atopic diseases in young children. Vitamin D has been shown to induce tolerogenic antigen-presenting cells such as dendritic cells. Whether the allergy-protective potential of prenatal vitamin D is mediated through such mechanisms is, however, unknown. Objective To evaluate the association between prenatal vitamin D supplementation and tolerogenic antigen-presenting cells in cord blood (CB) as determined by mRNA measurement of immunoglobulin-like transcripts (ILT)3 and ILT4. Methods A prospective multi-centre birth cohort was established in rural areas of five European countries. Information on maternal exposures including vitamin D intake was collected by questionnaires during pregnancy. The gene expression of ILT3 and ILT4 was analysed by real-time PCR in the CB of 927 children. Maternal vitamin D supplementation was assessed in Finland and France (n=349). Results Maternal vitamin D supplementation during pregnancy was associated with an increase in the gene expression of ILT3 (P=0.012) and ILT4 (P |
| اللغة: | English |
| تدمد: | 0954-7894 1365-2222 |
| DOI: | 10.1111/j.1365-2222.2009.03428.x⟩ |
| DOI: | 10.1111/j.1365-2222.2009.03428.x〉 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d277d2157c7fb106edc54383671fdcec https://hal.archives-ouvertes.fr/hal-00448394 |
| رقم الانضمام: | edsair.pmid.dedup....d277d2157c7fb106edc54383671fdcec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09547894 13652222 |
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| DOI: | 10.1111/j.1365-2222.2009.03428.x⟩ |