End points for phase II trials in intensive care: recommendations from the Australian and New Zealand Clinical Trials Group consensus panel meeting
| العنوان: | End points for phase II trials in intensive care: recommendations from the Australian and New Zealand Clinical Trials Group consensus panel meeting |
|---|---|
| المؤلفون: | Paul Young, Carol Hodgson, Joel Dulhunty, Manoj Saxena, Michael John Bailey, Rinaldo Bellomo, Andrew Davies, Simon Finfer, Peter Kruger, Jeffrey Lipman, John Myburgh, Peake, Sandra L., Seppelt, Ian M., Stephen Streat, Rhiannaon Tate, Steve Webb |
| المصدر: | Scopus-Elsevier Monash University Imperial College London |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Clinical Trials, Phase II as Topic, Endpoint Determination, Critical Illness, Sample Size, Outcome Assessment, Health Care, Australia, Humans, New Zealand |
| الوصف: | There is uncertainty about which end points should be used for Phase II trials in critically ill patients.To systematically evaluate potential end points for Phase II trials in critically ill patients.A report outlining a process of literature review and recommendations from a consensus meeting conducted on behalf of the Australian and New Zealand Intensive Care Society Clinical Trials Group (ANZICS CTG) in October 2011.The consensus panel concluded that there are no adequately validated end points for Phase II trials in critically ill patients. However, the following were identified as potential Phase II end points: hospital-free days to Day 90, ICU-free days to Day 28, ventilator-free days to Day 28, cardiovascular support-free days to Day 28, and renal replacement therapy-free days to Day 28. We recommend that these end points be evaluated further. |
| تدمد: | 1441-2772 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::cf036ca67627ff73f225eb0439d0bde0 https://pubmed.ncbi.nlm.nih.gov/22963216 |
| رقم الانضمام: | edsair.pmid.dedup....cf036ca67627ff73f225eb0439d0bde0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14412772 |
|---|