Upregulation of SMYD3 and SMYD3 VNTR 3/3 polymorphism increase the risk of hepatocellular carcinoma
| العنوان: | Upregulation of SMYD3 and SMYD3 VNTR 3/3 polymorphism increase the risk of hepatocellular carcinoma |
|---|---|
| المؤلفون: | Binh, Mai Thanh, Hoan, Nghiem Xuan, Giang, Dao Phuong, Tong, Hoang Van, Bock, C.-Thomas, Wedemeyer, Heiner, Toan, Nguyen Linh, Bang, Mai Hong, Kremsner, Peter G., Meyer, Christian G., Song, Le Huu, Velavan, Thirumalaisamy P. |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Liver Cirrhosis, Male, Carcinoma, Hepatocellular, Adolescent, Hepatocellular carcinoma, Medizin, lcsh:Medicine, Minisatellite Repeats, Article, Young Adult, Hepatitis B, Chronic, Risk Factors, Humans, Genetic Predisposition to Disease, ddc:610, lcsh:Science, Child, Promoter Regions, Genetic, Aged, Aged, 80 and over, Polymorphism, Genetic, lcsh:R, Liver Neoplasms, Histone-Lysine N-Methyltransferase, Middle Aged, Hepatitis B, digestive system diseases, Gene Expression Regulation, Neoplastic, Case-Control Studies, lcsh:Q, Female, 610 Medizin und Gesundheit |
| الوصف: | SMYD3 (SET and MYND domain-containing protein 3) is involved in histone modification, which initiates oncogenesis by activating transcription of multiple downstream genes. To investigate associations of variable numbers of tandem repeats (VNTR) variants in the SMYD3 gene promoter, SMYD3 serum levels and SMYD3 mRNA expression in hepatitis B virus (HBV) infection and clinical progression of related liver disease. SMYD3 VNTRs were genotyped in 756 HBV patients and 297 healthy controls. SMYD3 serum levels were measured in 293 patients and SMYD3 mRNA expression was quantified in 48 pairs of hepatocellular tumor and adjacent non-tumor liver tissues. Genotype SYMD3 VNTR 3/3 was more frequent among HCC patients than in controls (Padjusted = 0.037). SMYD3 serum levels increased according to clinical progression of liver diseases (P = 0.01); HCC patients had higher levels than non-HCC patients (P = 0.04). Among patients with SMYD3 VNTR 3/3, HCC patients had higher SMYD3 levels than others (P |
| وصف الملف: | application/pdf |
| تدمد: | 2045-2322 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a79fceaa525c37158bd05489fb204319 https://pubmed.ncbi.nlm.nih.gov/32071406 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....a79fceaa525c37158bd05489fb204319 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|