Successful outcome of disseminated mucormycosis in a 3-year-old child suffering from acute leukaemia: the role of isavuconazole? A case report
| العنوان: | Successful outcome of disseminated mucormycosis in a 3-year-old child suffering from acute leukaemia: the role of isavuconazole? A case report |
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| المؤلفون: | Cornu, M. (Marjorie), Bruno, B. (Benedicte), Loridant, S. (Severine), Navarin, P. (Pauline), Francois, N. (Nadine), Lanternier, F. (Fanny), Amzallag-Bellenger, E. (Elisa), Dubos, F. (Francois), Mazingue, F. (Francoise), Sendid, B. (Boualem) |
| المساهمون: | Lille Inflammation Research International Center - U 995 (LIRIC), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Mycologie moléculaire - Molecular Mycology, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Centre National de Référence Mycoses Invasives et Antifongiques - National Reference Center Invasive Mycoses & Antifungals (CNRMA), Institut Pasteur [Paris], Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), This work was supported by internal funding 'Fonds d’aide à l’émergence et à l’excellence du CHRU de Lille-Bonus H'., Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP), Lille Inflammation Research International Center (LIRIC), Centre d'infectiologie Necker-Pasteur [CHU Necker], CHU Necker - Enfants Malades [AP-HP], Santé publique : épidémiologie et qualité des soins-EA 2694 (CERIM), Université de Lille, LillOA, CHU Lille, Inserm, Université de Lille, Lille Inflammation Research International Center - U 995 [LIRIC], Lille Inflammation Research International Center (LIRIC) - U995, Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS] |
| المصدر: | BMC Pharmacology and Toxicology BMC Pharmacology and Toxicology, BioMed Central, 2018, 19, pp.81. ⟨10.1186/s40360-018-0273-7⟩ BMC Pharmacology and Toxicology, 2018, 19, pp.81. ⟨10.1186/s40360-018-0273-7⟩ BMC Pharmacology & Toxicology BMC Pharmacology and Toxicology, Vol 19, Iss 1, Pp 1-5 (2018) |
| بيانات النشر: | HAL CCSD, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | MESH: Leukemia, B-Cell/drug therapy, Antifungal Agents, Pyridines, Case Report, Isavuconazole, Mucormycosis, Paediatrics, Drug-monitoring, Lichtheimia, MESH: Mucormycosis/drug therapy, [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics, lcsh:RA1190-1270, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Amphotericin B, Nitriles, Leukemia, B-Cell, MESH: Pyridines/therapeutic use, Humans, MESH: Nitriles/therapeutic use, lcsh:Toxicology. Poisons, MESH: Treatment Outcome, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, MESH: Humans, lcsh:RM1-950, MESH: Child, Preschool, Triazoles, MESH: Amphotericin B/therapeutic use, MESH: Drug Therapy, Combination, lcsh:Therapeutics. Pharmacology, Treatment Outcome, MESH: Antifungal Agents/therapeutic use, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, Child, Preschool, Acute Disease, [SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases, MESH: Triazoles/therapeutic use, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, MESH: Acute Disease, Drug Therapy, Combination, Female, MESH: Female |
| الوصف: | International audience; BACKGROUND: The use of isavuconazole is approved for the management of invasive aspergillosis and mucormycosis, only in adults, as no paediatric pharmacology studies have been reported to date. Very few paediatric cases have been published concerning the use of isavuconazole. Amphotericin B is the only antifungal agent recommended in paediatric mucormycosis, but adverse effects and especially nephrotoxicity, even with the liposomal formulation, could be problematic. In this context, the use of other antifungal molecules active on Mucorales becomes needful.METHODS: We describe a case of mucormycosis with rapid onset dissemination in a 3-year-old girl recently diagnosed with acute lymphocytic leukaemia. She was successfully treated with isavuconazole alone and then in combination with liposomal amphotericin B. Isavuconazole therapy was guided by therapeutic drug monitoring.CONCLUSIONS: This case offers new perspectives on the potential use of isavuconazole in children with mucormycosis, as an alternative or adjunct to liposomal amphotericin B. |
| وصف الملف: | application/pdf; application/octet-stream; application/rdf+xml; charset=utf-8 |
| اللغة: | English |
| تدمد: | 2050-6511 |
| DOI: | 10.1186/s40360-018-0273-7⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a5df56e3e658199eb6c2d370927882d4 https://hal.univ-lille.fr/hal-02513581/document |
| Rights: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....a5df56e3e658199eb6c2d370927882d4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20506511 |
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| DOI: | 10.1186/s40360-018-0273-7⟩ |