التفاصيل البيبلوغرافية
| العنوان: |
'Suspicious' salivary gland FNA: Risk of malignancy and interinstitutional variability |
| المؤلفون: |
Maleki, Z, Miller, Ja, Arab, Se, Fadda, Guido, Bo, P, Wise, O, Rossi, Ed, Jhala, N, Ashish, C, Ali, Sz, Wang, H |
| المصدر: |
Cancer cytopathology. 126(2) |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
Adult, Male, China, Adolescent, Biopsy, Fine-Needle, salivary gland, Risk Assessment, Salivary Glands, Young Adult, suspicious, Prevalence, Humans, risk of malignancy, Child, fine-needle aspiration (FNA), interinstitutional variability, Aged, Aged, 80 and over, Observer Variation, Settore MED/08 - ANATOMIA PATOLOGICA, Infant, Newborn, Infant, Cytology, fine-needle aspiration (FNA), interinstitutional variability, risk of malignancy, salivary gland, suspicious, adolescent, adult, aged, aged, 80 and over, biopsy, fine-needle, child, child, preschool, China, Europe, female, follow-up studies, humans, infant, infant, newborn, male, middle aged, observer variation, prevalence, risk assessment, salivary gland neoplasms, salivary glands, United States, young adult, Middle Aged, Salivary Gland Neoplasms, United States, Europe, Child, Preschool, cytology, Female, Follow-Up Studies |
| الوصف: |
Fine-needle aspiration (FNA) cytology is well accepted as a safe, reliable, minimally invasive, and cost-effective method for the diagnosis of salivary gland lesions. Salivary gland neoplasms are often difficult to diagnose because of morphologic heterogeneity and a variety of epithelial metaplastic changes. Hence, a number of salivary gland FNA specimens yield indeterminate results. For indeterminate FNA specimens, the suspicious-for-malignancy (SFM) category is used when a specific neoplasm falls short in quantity or quality for the criteria for malignancy. Therefore, the findings are not sufficient for a conclusive diagnosis of malignancy.This study was designed to evaluate the risk of malignancy (ROM) for the SFM group at 5 tertiary medical centers worldwide with the aforementioned criteria. Among 12,606 salivary gland FNA cases between 1997 and 2014, 276 (2.2%) were reported to be SFN. Specifically, 114 suspicious cases (41%) had histological follow-up.Histological follow-up of the 114 suspicious cases showed 95 malignant tumors indicating a risk of malignancy (ROM) of 83.3%. The ROM varied between 74% and 88% for the 5 participating institutions, and a Fisher's exact test with significance set to p.05 showed no significant difference in ROM among the institutions (p = .78).Overall, 83.3% of SFM salivary gland FNA specimens turned out to be malignant; there was no significant interinstitutional variability in the ROMs. The SFM category for salivary gland FNA is very homogeneous, and the ROMs are quite similar worldwide. Cancer Cytopathol 2018;126:94-100. © 2017 American Cancer Society. |
| تدمد: |
1934-6638 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a1aef5932fba168bb49b9ce861bd33d3
https://pubmed.ncbi.nlm.nih.gov/29053216 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.pmid.dedup....a1aef5932fba168bb49b9ce861bd33d3 |
| قاعدة البيانات: |
OpenAIRE |