[Secretion and role of autotaxin and lysophosphatidic acid in adipose tissue]
| العنوان: | [Secretion and role of autotaxin and lysophosphatidic acid in adipose tissue] |
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| المؤلفون: | Jean Sébastien, Saulnier-Blache |
| المساهمون: | Unité de recherche sur les obésités, IFR 31 Louis Bugnard (IFR 31), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Saulnier-Blache, Jean Sébastien |
| المصدر: | Journal de la Société de Biologie Journal de la Société de Biologie, 2006, 200 (1), pp.77-81 |
| بيانات النشر: | HAL CCSD, 2006. |
| سنة النشر: | 2006 |
| مصطلحات موضوعية: | MESH: Pyrophosphatases, MESH: Receptors, G-Protein-Coupled, [SDV.BC]Life Sciences [q-bio]/Cellular Biology, MESH: Multienzyme Complexes, Receptors, G-Protein-Coupled, MESH: Lysophospholipids, MESH: Phosphodiesterase I, Multienzyme Complexes, Adipocytes, Homeostasis, Humans, MESH: Obesity, Obesity, Pyrophosphatases, [SDV.BC] Life Sciences [q-bio]/Cellular Biology, MESH: Adipocytes, MESH: Humans, Phosphoric Diester Hydrolases, Adipose Tissue, Diabetes Mellitus, Type 2, Phosphodiesterase I, MESH: Homeostasis, MESH: Cell Division, lipids (amino acids, peptides, and proteins), Lysophospholipids, MESH: Phosphoric Diester Hydrolases, Cell Division, MESH: Adipose Tissue, MESH: Diabetes Mellitus, Type 2 |
| الوصف: | International audience; In obesity, adipocyte hypertrophy is often associated with recrutement of new fat cells (adipogenesis) under the control of circulating and local regulatory factors. Among the different lipids released in the extracellular compartment of adipocytes, our group found the presence of lysophosphatidic acid (LPA). LPA is a bioactive phospholipid able to regulate several cell responses via the activation of specific G-protein coupled membrane receptors. Our group found that LPA increases preadipocyte proliferation and inhibits adipogenesis via the activation of LPA1 receptor subtype. Extracellular LPA-synthesis is catalyzed by a lysophospholipase D secreted by adipocytes: autotaxin (ATX). Adipocyte ATX expression strongly increases with adipogenesis as well as in individuals exhibiting type 2 diabetes associated with massive obesity. A possible contribution of ATX and LPA as paracrine regulators of adipogenesis and obesity associated diabetes is proposed. |
| اللغة: | French |
| تدمد: | 1295-0661 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::94aaebd8a6d1dd28278d8af9699381f8 https://www.hal.inserm.fr/inserm-00274865 |
| رقم الانضمام: | edsair.pmid.dedup....94aaebd8a6d1dd28278d8af9699381f8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 12950661 |
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