Ammonium and guanidinium dendron-carbon nanotubes by amidation and click chemistry and their use for siRNA delivery
| العنوان: | Ammonium and guanidinium dendron-carbon nanotubes by amidation and click chemistry and their use for siRNA delivery |
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| المؤلفون: | Battigelli, A. (Alessia), Wang, J. (Julie Tzu-Wen), Russier, J. (Julie), Da Ros, T. (Tatiana), Kostarelos, K. (Kostas), Al-Jamal, K. (Khuloud T), Prato, M. (Maurizio), Bianco, A. (Alberto) |
| المساهمون: | Immunopathologie et chimie thérapeutique (ICT), Institut de biologie moléculaire et cellulaire (IBMC), Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS), BB/J008656/1, Alessia, Battigelli, Julie Tzu Wen, Wang, Julie, Russier, DA ROS, Tatiana, Kostas, Kostarelo, Khuloud T., Al Jamal, Prato, Maurizio, Alberto, Bianco |
| المصدر: | Small Small, Wiley-VCH Verlag, 2013, 9 (21), pp.3610-3619. ⟨10.1002/smll.201300264⟩ |
| بيانات النشر: | HAL CCSD, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | administration & dosage, genetics, siRNA delivery, cationic dendrons, carbon nanotubes, Nanotubes, Carbon, Carbon Nanotube, RNA delivery, [CHIM.THER]Chemical Sciences/Medicinal Chemistry, chemistry, Amides, gene therapy, Carbon Nanotubes, Microscopy, Electron, Transmission, siRNA, Ammonium Compounds, Click Chemistry, Chimie/Chimie thérapeutique, Gene Silencing, RNA, Small Interfering, Guanidine |
| الوصف: | A series of multi-walled carbon nanotube (MWCNT) conjugates is described, functionalized with different dendrons bearing positive charges at their termini (i.e. ammonium or guanidinium groups). The dendrimeric units are anchored to the nanotube scaffolds using two orthogonal synthetic approaches, amidation and click reactions. The final nanohybrids are characterized by complementary analytical techniques, while their ability to interact with siRNA is investigated by means of agarose gel electrophoresis. The demonstration of the cell uptake capacity, the low cytotoxicity, and the ability of these cationic conjugates to silence cytotoxic genes suggests them to be promising carriers for genetic material. journal article research support, non-u.s. gov't 2013 Nov 11 2013 05 06 imported |
| اللغة: | English |
| تدمد: | 1613-6810 1613-6829 |
| DOI: | 10.1002/smll.201300264⟩ |
| DOI: | 10.1002/smll.201300264 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::88b458869c533369fa9ebf6e0047d4ad https://hal.archives-ouvertes.fr/hal-02558870/document |
| Rights: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....88b458869c533369fa9ebf6e0047d4ad |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16136810 16136829 |
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| DOI: | 10.1002/smll.201300264⟩ |