Is it necessary to treat all patients with idiopathic pulmonary fibrosis?
| العنوان: | Is it necessary to treat all patients with idiopathic pulmonary fibrosis? |
|---|---|
| المؤلفون: | Xaubet, A., Agustí, C., Luburich, P., Roca, J., Carmen Ayuso, Marrades, R. M., Rodriguez-Roisin, R. |
| المصدر: | Europe PubMed Central Scopus-Elsevier |
| مصطلحات موضوعية: | Aged, 80 and over, Male, Pulmonary Fibrosis, Humans, Female, Prospective Studies, Middle Aged, Bronchoalveolar Lavage, Aged, Follow-Up Studies, Respiratory Function Tests |
| الوصف: | To investigate the clinical course of untreated patients with idiopathic pulmonary fibrosis (usual interstitial pneumonia) (IPF/UIP).Forty-three patients with IPF/UIP, divided into two groups. Group I consisted of 29 patients treated at diagnosis, while Group II comprised 14 patients who did not receive treatment. The indication of treatment was established whenever patients referred to a significant progression of the degree of dyspnea during the year prior to diagnosis.At diagnosis, patients from Group I had lower FVC (mean +/- SEM, 56+/-3% vs 73+/-3%) (p = 0.0004) and a greater extent of ground glass pattern in high resolution CT scan (18+/-4% vs 4+/-1%) (p = 0.004) than those from Group II. In group I, a follow-up study was carried out on 26 patients for 24+/-4 months. Thirteen of these 26 patients (50%) died 11+/-4 months after the initial assessment. Serial pulmonary functional tests were performed on 19 patients. Thirteen patients from Group II were followed up for 23+/-3 months. Seven of these 13 patients were treated 12+/-3 months after the diagnosis because of progression of the disease. The remaining 6 patients remained untreated and with the disease stable at the end of the follow-up, representing 15% (6 out of 39) of the whole study group. No patients from this group died during the follow-up. At the end of the follow-up, there were no differences in lung function changes between treated patients (19 from Group I and 7 from Group II), and the 6 untreated patients.Some patients with IPF/UIP remain stable for extended periods of time without treatment. |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::75aa6fca7e37d85d306f2107961018be http://europepmc.org/abstract/med/11587101 |
| رقم الانضمام: | edsair.pmid.dedup....75aa6fca7e37d85d306f2107961018be |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |