التفاصيل البيبلوغرافية
| العنوان: |
The Down syndrome brain in the presence and absence of fibrillar β-amyloidosis |
| المؤلفون: |
Annus, Tiina, Wilson, Liam R., Acosta-Cabronero, Julio, Cardenas-Blanco, Arturo, Hong, Young T., Fryer, Tim D., Coles, Jonathan P., Menon, David K., Zaman, Shahid H., Holland, Anthony J., Nestor, Peter J. |
| المساهمون: |
Coles, Jonathan [0000-0003-4013-679X], Menon, David [0000-0002-3228-9692], Zaman, Shahid [0000-0003-1639-6014], Holland, Anthony [0000-0003-4107-130X], Apollo - University of Cambridge Repository |
| المصدر: |
Neurobiology of aging 53, 11-19 (2017). doi:10.1016/j.neurobiolaging.2017.01.009
Neurobiology of Aging |
| بيانات النشر: |
Elsevier BV, 2017. |
| سنة النشر: |
2017 |
| مصطلحات موضوعية: |
Adult, Male, Down syndrome, Neuroscience(all), 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole, Clinical Neurology, metabolism [Amyloid beta-Peptides], diagnostic imaging [Amyloidosis], Neuroimaging, pathology [Alzheimer Disease], Alzheimer Disease, pathology [Gray Matter], mental disorders, diagnostic imaging [Cerebral Cortex], Humans, ddc:610, Gray Matter, gray matter volume, pathology [Down Syndrome], Aged, Cerebral Cortex, Aniline Compounds, Amyloid beta-Peptides, Brain Diseases, Metabolic, pathology [Brain Diseases, Metabolic], diagnostic imaging [Gray Matter], amyloid, Regular Article, Amyloidosis, Alzheimer's disease, cortical thickness, Middle Aged, diagnostic imaging [Brain Diseases, Metabolic], Magnetic Resonance Imaging, Thiazoles, Ageing, Cross-Sectional Studies, pathology [Cerebral Cortex], Female, pathology [Amyloidosis], Geriatrics and Gerontology, diagnostic imaging [Down Syndrome], Developmental Biology |
| الوصف: |
People with Down syndrome (DS) have a neurodevelopmentally distinct brain and invariably developed amyloid neuropathology by age 50. This cross-sectional study aimed to provide a detailed account of DS brain morphology and the changes occuring with amyloid neuropathology. Forty-six adults with DS underwent structural and amyloid imaging—the latter using Pittsburgh compound B (PIB) to stratify the cohort into PIB-positive (n = 19) and PIB-negative (n = 27). Age-matched controls (n = 30) underwent structural imaging. Group differences in deep gray matter volumetry and cortical thickness were studied. PIB-negative people with DS have neurodevelopmentally atypical brain, characterized by disproportionately thicker frontal and occipitoparietal cortex and thinner motor cortex and temporal pole with larger putamina and smaller hippocampi than controls. In the presence of amyloid neuropathology, the DS brains demonstrated a strikingly similar pattern of posterior dominant cortical thinning and subcortical atrophy in the hippocampus, thalamus, and striatum, to that observed in non-DS Alzheimer's disease. Care must be taken to avoid underestimating amyloid-associated morphologic changes in DS due to disproportionate size of some subcortical structures and thickness of the cortex. |
| وصف الملف: |
application/pdf |
| تدمد: |
0197-4580 |
| DOI: |
10.1016/j.neurobiolaging.2017.01.009 |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::63b7e55f23abc0a336807769911cf737 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.pmid.dedup....63b7e55f23abc0a336807769911cf737 |
| قاعدة البيانات: |
OpenAIRE |