Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients
| العنوان: | Proficiency of transient elastography compared to liver biopsy for the assessment of fibrosis in HIV/HBV-coinfected patients |
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| المؤلفون: | P, Miailhes, P, Pradat, M, Chevallier, K, Lacombe, F, Bailly, L, Cotte, M-A, Trabaud, A, Boibieux, J, Bottero, C, Trepo, F, Zoulim |
| المساهمون: | Equipe 15, Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Equipe 16, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Hôpital de la Croix-Rousse [CHU - HCL], Hospices Civils de Lyon (HCL), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU) |
| المصدر: | Journal of Viral Hepatitis Journal of Viral Hepatitis, Wiley-Blackwell, 2011, 18 (1), pp.61-9. ⟨10.1111/j.1365-2893.2010.01275.x⟩ |
| بيانات النشر: | HAL CCSD, 2011. |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Liver Cirrhosis, Male, Hepatitis B virus, Biopsy, HIV Infections, MESH: Algorithms, [SDV.CAN]Life Sciences [q-bio]/Cancer, MESH: Elasticity Imaging Techniques, MESH: HIV-1, Young Adult, MESH: Biopsy, Humans, MESH: Middle Aged, MESH: Humans, MESH: Hepatitis B, MESH: Adult, MESH: HIV Infections, Middle Aged, Hepatitis B, MESH: Male, MESH: Hepatitis B virus, Liver, MESH: Young Adult, HIV-1, Elasticity Imaging Techniques, Female, MESH: Liver Cirrhosis, MESH: Female, Algorithms, MESH: Liver |
| الوصف: | International audience; Transient elastography (TE) is a noninvasive technique to evaluate liver fibrosis. We compared the performance of TE with liver biopsy (LB) in patients with human immunodeficiency virus (HIV) and hepatitis B virus (HBV) coinfection. Patients prospectively underwent TE and LB. The diagnosis accuracy of TE was calculated using receiver operating characteristic (ROC) curves for different stages of fibrosis, and optimal cut-off values were defined. A sequential algorithm combining TE with biochemical score (Fibrotest) is proposed. Fifty-seven patients had both TE and LB (median time: 3 days) and two with proven cirrhosis, only TE. Forty-six (78%) were under antiretroviral therapy with anti-HBV drugs in 98%, and 19 (32%) had elevated alanine aminotransferase (ALT). A significant correlation was observed between liver stiffness measurement (LSM) and METAVIR fibrosis stages (P < 0.0001). Patients with elevated ALT tended to have higher LSM than those with normal ALT. The areas under the ROC curves were 0.85 for significant fibrosis (≥ F2), 0.92 for advanced fibrosis (≥ F3) and 0.96 for cirrhosis. Using a cut-off of 5.9 kPa for F ≥ 2 and 7.6 kPa for F ≥ 3, the diagnosis accuracy was 83% and 86%, respectively. With an algorithm combining TE and Fibrotest, 97% of patients were well classified for significant fibrosis. Using this algorithm, the need for LB can be reduced by 67%. In HIV/HBV-coinfected patients, most of them with normal ALT under antiretroviral treatment including HBV active drugs, TE was proficient in discriminating moderate to severe fibrosis from minimal liver disease. |
| اللغة: | English |
| تدمد: | 1352-0504 1365-2893 |
| DOI: | 10.1111/j.1365-2893.2010.01275.x⟩ |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::62cb56c3d50ac5d996e2c43f0b6a6108 https://hal.archives-ouvertes.fr/hal-00851726 |
| رقم الانضمام: | edsair.pmid.dedup....62cb56c3d50ac5d996e2c43f0b6a6108 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13520504 13652893 |
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| DOI: | 10.1111/j.1365-2893.2010.01275.x⟩ |