Genome-Wide Association and Functional Studies Identify

التفاصيل البيبلوغرافية
العنوان: Genome-Wide Association and Functional Studies Identify
المؤلفون: Yang, Li, Dao Wen, Wang, Yundai, Chen, Can, Chen, Jian, Guo, Shu, Zhang, Zhijun, Sun, Hu, Ding, Yan, Yao, Lei, Zhou, Ke, Xu, Chun, Song, Fan, Yang, Bin, Zhao, Han, Yan, Wen-Jing, Wang, Chong, Wu, Xiangfeng, Lu, Xueli, Yang, Jie, Dong, Guyan, Zheng, Shuhan, Tian, Yanjun, Cui, Lijuan, Jin, Gangqiong, Liu, Hanbin, Cui, Shenghuang, Wang, Feng, Jiang, Changhua, Wang, Jeanette, Erdmann, Linyao, Zeng, Shian, Huang, Jianfeng, Zhong, Yuehua, Ma, Wenjiang, Chen, Jianli, Sun, Wei, Lei, Shenghan, Chen, Shaoqi, Rao, Dongfeng, Gu, Heribert, Schunkert, Xiao-Li, Tian
المصدر: Arteriosclerosis, thrombosis, and vascular biology. 38(4)
سنة النشر: 2017
مصطلحات موضوعية: Adult, Male, China, Polycomb-Group Proteins, Coronary Artery Disease, Vascular Remodeling, Polymorphism, Single Nucleotide, Rats, Sprague-Dawley, Asian People, Gene Frequency, Risk Factors, Human Umbilical Vein Endothelial Cells, Animals, Humans, Carotid Stenosis, Genetic Predisposition to Disease, Cells, Cultured, Aged, Middle Aged, Coronary Vessels, Disease Models, Animal, Carotid Arteries, Phenotype, Female, Thrombospondins, Genome-Wide Association Study
الوصف: The genetic contribution to coronary artery disease (CAD) remains largely unclear. We combined genetic screening with functional characterizations to identify novel loci and candidate genes for CAD.We performed genome-wide screening followed by multicenter validation in 8 cohorts consisting of 21 828 participants of Han ethnicity and identified 3 novel intragenic SNPs (single nucleotide polymorphisms), rs9486729 (We identify 3 novel loci associated with CAD and show that 2 genes
تدمد: 1524-4636
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::cf6daf798ba1611b509aeeb473afbf32
https://pubmed.ncbi.nlm.nih.gov/29472232
رقم الانضمام: edsair.pmid..........cf6daf798ba1611b509aeeb473afbf32
قاعدة البيانات: OpenAIRE