Is the use of cholesterol in mortality risk algorithms in clinical guidelines valid? Ten years prospective data from the Norwegian HUNT 2 study
| العنوان: | Is the use of cholesterol in mortality risk algorithms in clinical guidelines valid? Ten years prospective data from the Norwegian HUNT 2 study |
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| المؤلفون: | Petursson, Halfdan, Sigurdsson, Johann A, Bengtsson, Calle, Nilsen, Tom I L, Getz, Linn |
| المصدر: | Journal of Evaluation in Clinical Practice |
| بيانات النشر: | Blackwell Publishing Ltd, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | primary care, Cholesterol, clinical guidelines, cardiovascular risk estimation, Commentaries, Practice Guidelines as Topic, Humans, preventive medicine, mortality, Algorithms |
| الوصف: | Rationale, aims and objectives Many clinical guidelines for cardiovascular disease (CVD) prevention contain risk estimation charts/calculators. These have shown a tendency to overestimate risk, which indicates that there might be theoretical flaws in the algorithms. Total cholesterol is a frequently used variable in the risk estimates. Some studies indicate that the predictive properties of cholesterol might not be as straightforward as widely assumed. Our aim was to document the strength and validity of total cholesterol as a risk factor for mortality in a well-defined, general Norwegian population without known CVD at baseline. Methods We assessed the association of total serum cholesterol with total mortality, as well as mortality from CVD and ischaemic heart disease (IHD), using Cox proportional hazard models. The study population comprises 52 087 Norwegians, aged 20–74, who participated in the Nord-Trøndelag Health Study (HUNT 2, 1995–1997) and were followed-up on cause-specific mortality for 10 years (510 297 person-years in total). Results Among women, cholesterol had an inverse association with all-cause mortality [hazard ratio (HR): 0.94; 95% confidence interval (CI): 0.89–0.99 per 1.0 mmol L−1 increase] as well as CVD mortality (HR: 0.97; 95% CI: 0.88–1.07). The association with IHD mortality (HR: 1.07; 95% CI: 0.92–1.24) was not linear but seemed to follow a ‘U-shaped’ curve, with the highest mortality |
| اللغة: | English |
| تدمد: | 1365-2753 1356-1294 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::ced7d208d9419163c03f422ad8081596 http://europepmc.org/articles/PMC3303886 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.pmid..........ced7d208d9419163c03f422ad8081596 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652753 13561294 |
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