Clade distribution of
| العنوان: | Clade distribution of |
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| المؤلفون: | Serisha D, Naicker, Tsidiso G, Maphanga, Nancy A, Chow, Mushal, Allam, Stanford, Kwenda, Arshad, Ismail, Nelesh P, Govender |
| المصدر: | Emerging Microbes & Infections article-version (VoR) Version of Record |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, whole genome sequencing, Antifungal Agents, Adolescent, clades, Candidiasis, Infant, Newborn, Candidemia, Infant, Microbial Sensitivity Tests, Middle Aged, Candida auris, South Africa, Young Adult, single nucleotide polymorphisms, Drug Resistance, Fungal, Child, Preschool, Humans, Genome, Fungal, Child, Phylogeny, Research Article, Aged, Candida |
| الوصف: | In South Africa, Candida auris was the third most common cause of candidemia in 2016–2017. We performed single nucleotide polymorphism (SNP) genome-wide analysis of 115 C. auris isolates collected between 2009 and 2018 from national laboratory-based surveillance, an environmental survey at four hospitals and a colonization study during a neonatal unit outbreak. The first known South African C. auris strain from 2009 clustered in clade IV. Overall, 98 strains clustered within clade III (85%), 14 within clade I (12%) and three within clade IV (3%). All environmental and colonizing strains clustered in clade III. We also identified known clade-specific resistance mutations in the ERG11 and FKS1 genes. Identification of clade I strains between 2016 and 2018 suggests introductions from South Asia followed by local transmission. SNP analysis characterized most C. auris strains into clade III, the clade first reported from South Africa, but the presence of clades I and IV strains also suggest early introductions from other regions. |
| تدمد: | 2222-1751 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::cd435378b927cb56698718c4f8398e6a https://pubmed.ncbi.nlm.nih.gov/34176429 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.pmid..........cd435378b927cb56698718c4f8398e6a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22221751 |
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