In this study, we aimed to investigate the role of ATP-sensitive potassium (KRat thoracic aorta ring preparations and cultured thoracic aorta cells were divided into four groups as control, 2mM NAC, 5mM NAC, and 10mM NAC. Thoracic aorta rings were isolated from rats for measurements of relaxation responses and NaThe relaxation rate significantly increased in all NAC groups compared to control. Similarly, NaOur findings suggest that NAC relaxes vascular smooth muscle cells through a direct effect on K