Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals
| العنوان: | Vangl-dependent planar cell polarity signalling is not required for neural crest migration in mammals |
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| المؤلفون: | Pryor, Sophie E., Massa, Valentina, Savery, Dawn, Andre, Philipp, Yang, Yingzi, Greene, Nicholas D. E., Copp, Andrew J. |
| المصدر: | Development (Cambridge, England) |
| بيانات النشر: | The Company of Biologists, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Neural Tube, Mouse, Homozygote, Cell Polarity, Membrane Proteins, Research Reports, Cell Differentiation, Nerve Tissue Proteins, Planar cell polarity, Neural crest, Mice, Embryo, Cell Movement, Mutation, Animals, Cell migration, Cell Lineage, Carrier Proteins, Alleles, Signal Transduction |
| الوصف: | The role of planar cell polarity (PCP) signalling in neural crest (NC) development is unclear. The PCP dependence of NC cell migration has been reported in Xenopus and zebrafish, but NC migration has not been studied in mammalian PCP mutants. Vangl2(Lp/Lp) mouse embryos lack PCP signalling and undergo almost complete failure of neural tube closure. Here we show, however, that NC specification, migration and derivative formation occur normally in Vangl2(Lp/Lp) embryos. The gene family member Vangl1 was not expressed in NC nor ectopically expressed in Vangl2(Lp/Lp) embryos, and doubly homozygous Vangl1/Vangl2 mutants exhibited normal NC migration. Acute downregulation of Vangl2 in the NC lineage did not prevent NC migration. In vitro, Vangl2(Lp/Lp) neural tube explants generated emigrating NC cells, as in wild type. Hence, PCP signalling is not essential for NC migration in mammals, in contrast to its essential role in neural tube closure. PCP mutations are thus unlikely to mediate NC-related birth defects in humans. |
| اللغة: | English |
| تدمد: | 1477-9129 0950-1991 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::b3bf0c590e67447792b930bbce4a3328 http://europepmc.org/articles/PMC4197537 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.pmid..........b3bf0c590e67447792b930bbce4a3328 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779129 09501991 |
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