SNEV
| العنوان: | SNEV |
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| المؤلفون: | Abdulhameed, Khan, Hanna, Dellago, Lucia, Terlecki-Zaniewicz, Michael, Karbiener, Sylvia, Weilner, Florian, Hildner, Viktoria, Steininger, Christian, Gabriel, Christoph, Mück, Pidder, Jansen-Dürr, Ara, Hacobian, Marcel, Scheideler, Regina, Grillari-Voglauer, Markus, Schosserer, Johannes, Grillari |
| المصدر: | Stem Cell Reports |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adipogenesis, Prp19, Gene Expression, Nuclear Proteins, Cell Differentiation, Pso4, SNEV, C. elegans, WRN, human adipose stromal cells, body regions, PPAR gamma, Oxidative Stress, DNA Repair Enzymes, Adipose Tissue, Gene Knockdown Techniques, Report, Animals, Humans, Insulin, DNA damage repair, RNA Splicing Factors, Stromal Cells, Caenorhabditis elegans, DNA Damage |
| الوصف: | Summary Aging is accompanied by loss of subcutaneous adipose tissue. This may be due to reduced differentiation capacity or deficiency in DNA damage repair (DDR) factors. Here we investigated the role of SNEVhPrp19/hPso4, which was implicated in DDR and senescence evasion, in adipogenic differentiation of human adipose stromal cells (hASCs). We showed that SNEV is induced during adipogenesis and localized both in the nucleus and in the cytoplasm. Knockdown of SNEV perturbed adipogenic differentiation and led to accumulation of DNA damage in hASCs upon oxidative stress. In addition, we demonstrated that SNEV is required for fat deposition in Caenorhabditis elegans. Consequently, we tested other DDR factors and found that WRN is also required for adipogenesis in both models. These results demonstrate that SNEV regulates adipogenesis in hASCs and indicate that DDR capacity in general might be a pre-requisite for this process. Graphical Abstract Highlights • SNEV is required for adipogenic differentiation of human adipose stromal cells • SNEV modulates pro- and anti-adipogenic signaling pathways • SNEV regulates DNA repair capacity of human adipose stromal cells • SNEV modulates organismal fat deposition in Caenorhabditis elegans How does a DNA repair factor regulate adipogenic differentiation and organismal fat deposition? Grillari, Schosserer and colleagues have shown that the essential splicing and DNA repair factor, SNEVhPrp19/hPso4, modulates pro- and anti-adipogenic signaling pathways and ensures genome integrity during adipocyte differentiation, suggesting a novel failsafe mechanism to avoid accumulation of dysfunctional cells. |
| تدمد: | 2213-6711 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::ae8ea5ae7241eda09af14c6a8e013863 https://pubmed.ncbi.nlm.nih.gov/28041875 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.pmid..........ae8ea5ae7241eda09af14c6a8e013863 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22136711 |
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