RP-HPTLC Retention Data in Correlation with the In-silico ADME Properties of a Series of s-triazine Derivatives
| العنوان: | RP-HPTLC Retention Data in Correlation with the In-silico ADME Properties of a Series of s-triazine Derivatives |
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| المؤلفون: | Jevrić, Lidija R, Podunavac-Kuzmanović, Sanja O, Švarc-Gajić, Jaroslava V, Kovačević, Strahinja Z, Jovanović, Bratislav Ž |
| المصدر: | Iranian Journal of Pharmaceutical Research : IJPR |
| بيانات النشر: | Shaheed Beheshti University of Medical Sciences, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | PCA, ADME, In-silico, Original Article, s-triazine derivatives, Polynomial regression |
| الوصف: | The properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by Quantitative structure-retention relationship (QSRR) approach. The chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (RP-HPTLC). Chromatographic retention (R M (0)) was correlated with selected physicochemical parameters relevant to pharmacokinetics, i.e. ADME (absorption, distribution, metabolism and excretion). In addition, the ability to act as kinase inhibitors and protease inhibitors was predicted for all investigated triazine classes. Also, in order to confirm similarities/dissimilarities between series of examined compounds, principal component analysis (PCA) based on calculated ADME properties was conducted. The R M (0) values of the s-triazine derivatives have been recommended for description and evaluation of pharmacokinetic properties. According to results of this study, the synthesized s-triazine derivatives meet pharmacokinetic criteria of preselection for drug candidates. |
| اللغة: | English |
| تدمد: | 1726-6890 1735-0328 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=pmid________::8fbefaf27c0e9b737869d34c394d371d http://europepmc.org/articles/PMC4232785 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.pmid..........8fbefaf27c0e9b737869d34c394d371d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17266890 17350328 |
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