The review of literature is devoted to up-to-date tendency of pharmacological treatment of corneal ulcers. Depending on cause of corneal inflammation treatment should be effective using appropriate etiotropic and pathogenetic treatment. Evaluating the literature data it is obvious that a number of questions is still should be studied. Thereby a search of new effective pharmacological treatment options with minimal side effects is essential. In case of progressing ulceration with threatened corneal perforation an urgent surgery is essential.