Increases in ambient levels of ozone (OThe primary goals of this study were: Aim 1 - to define the role of SR-BI in OTo address Aim 1, female wild-type (WT) and SR-BI-deficient, or knock-out (SR-BI KO), mice were exposed to either OTo address Aim 2, male WT mice were exposed to either OFor Aim 1, SR-BI protein levels increased in the lung tissue of mice exposed to OFor Aim 2, mice given SPM supplementation before OOur findings identify novel mechanisms by which O