The reaction of Pt-antitumor drugs with selected nucleophiles. I. The reaction of cis-[Pt(NH3)2Cl2] with glycine

التفاصيل البيبلوغرافية
العنوان: The reaction of Pt-antitumor drugs with selected nucleophiles. I. The reaction of cis-[Pt(NH3)2Cl2] with glycine
المؤلفون: H, Pivcová, V, Saudek, D, Nosková, J, Drobnik
المصدر: Journal of inorganic biochemistry. 23(1)
سنة النشر: 1985
مصطلحات موضوعية: Electrophoresis, Chemistry, Magnetic Resonance Spectroscopy, Time Factors, Chemical Phenomena, Glycine, Molecular Conformation, Temperature, Antineoplastic Agents, Spectrophotometry, Ultraviolet, Cisplatin, Hydrogen-Ion Concentration, Chromatography, High Pressure Liquid
الوصف: Various Pt(II)-glycine coordination compounds were characterized by 1H and 13C NMR spectroscopy, some of them also by electrophoretic and chromatographic behavior. The results were applied to the analysis of the reaction mixtures of cis-[Pt(NH3)2Cl2] and glycine obtained under various conditions. Cis-[Pt(NH3)2Cl2] reacts with glycine to give cis-diammine-(glycine-N,O)-Pt(II) and cis-diammine-bis(glycine-N-)Pt(II). Their ratio depends primarily on the pH of the reaction medium. Conformation of these compounds is discussed based on the observed Pt-C and Pt-H NMR coupling constants.
تدمد: 0162-0134
URL الوصول: https://explore.openaire.eu/search/publication?articleId=pmid________::548ff152ec1fa7ce1a27d89615203e53
https://pubmed.ncbi.nlm.nih.gov/4038994
رقم الانضمام: edsair.pmid..........548ff152ec1fa7ce1a27d89615203e53
قاعدة البيانات: OpenAIRE