Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities
| العنوان: | Teratogenic Effect of Ethylene Glycol-Methyl Cellosolve Mixture in Rats: II. Craniofacial and Limb Abnormalities |
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| المؤلفون: | García-Peláez,Isabel, Aguirre-Luna,Oswaldo M, Saavedra-Ontiveros,Dolores, Arteaga-Martínez,Manuel |
| المصدر: | International Journal of Morphology v.28 n.4 2010 SciELO Chile CONICYT Chile instacron:CONICYT |
| بيانات النشر: | Sociedad Chilena de Anatomía, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Methyl cellosolve, embryonic structures, Teratogenesis, Rat fetuses, Glycol ethers, Ethylene glycol |
| الوصف: | We investigated the teratogenic effect of an ethylene glycol-methyl cellosolve mixture on gestating Wistar rats, that received a daily intraperitoneal dose of different concentration of the mixture on day 8 of gestation until day 20. Multivariate analysis and Post-Hoc Bonferroni tests were used and relative risk and attributable fraction were calculated. In rats treated with the mixture the number of live fetuses decreased and reabsorptions increased with increasing concentrations of the mixture, as well as the number of abnormal fetuses. Abnormalities consisted mainly in atypical craniofacial morphology, protruding tongue, edema, signs of growth delay and shorter limbs, their frequency and severity increased at higher concentrations of the mixture. We conclude that the ethylene glycol-methyl cellosolve mixture possesses a higher teratogenic potential than each of its constituents separately, producing external fetal abnormalities, growth delay, and increased fetal death. |
| وصف الملف: | text/html |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=od______3056::fb2576db554293a6ff69647b366d18f8 http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000400030 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.od......3056..fb2576db554293a6ff69647b366d18f8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |