التفاصيل البيبلوغرافية
| العنوان: |
Rare clinical manifestations in systemic lupus erythematosus: A review on frequency and clinical presentation |
| المؤلفون: |
Tani, C. Elefante, E. Arnaud, L. Barreira, S.C. Bulina, I. Cavagna, L. Costedoat-Chalumeau, N. Doria, A. Fonseca, J.E. Franceschini, F. Fredi, M. Iaccarino, L. Limper, M. Majnik, J. Nagy, G. Pamfil, C. Rednic, S. Reynolds, J.A. Tektonidou, M.G. Troldborg, A. Zanframundo, G. Mosca, M. |
| سنة النشر: |
2022 |
| الوصف: |
Objectives. The purpose of this study was to review the frequency and clinical presentation of the rarest clinical manifestations of systemic lupus erythematosus (SLE). Methods. A list of 6 rare SLE manifestations were defined: gastrointestinal, liver, pulmonary, cardiac, ocular and neurological manifestations. Each topic was assigned to a couple of authors to perform a literature search and article review. Results. In total, 149 articles were included in the literature review: 37 for gastrointestinal manifestations, 6 for liver manifestations, 27 for pulmonary manifestations, 50 for cardiac manifestations, 16 for ocular manifestations, 13 for neurological manifestations. Gastrointestinal disorders included several clinical presentations with variable frequency (from 0.5% to 10.7% of the cases); liver involvement included lupusrelated hepatitis (9.3%) and autoimmune hepatitis (2.3%). The rarest pulmonary manifestations identified were shrinking lung syndrome, described in 1.5% of patients, while interstitial lung disease and lupus pneumonia were reported in 4% and 3% of patients, respectively. Myocarditis and pulmonary hypertension were also rarely described in SLE patients although ranging from 0.4-16% and 1-14% respectively, depending on the methodology used for its identification. Ocular manifestations in SLE included some rare manifestations (reported in less than 5% of patients) and lupus retinopathy that is described in 1.2-28.8% of patients depending on methods of ascertainment. Aseptic meningitis and chorea were also confirmed as very rare manifestations being reported in less than 1% and in 0.3-2.4% of cases respectively. Conclusion. The results of this literature review provide the basis for a better understanding of some less-known manifestations of SLE and for stressing the need for a higher awareness in diagnostic and therapeutic protocols regarding these rare disease aspects. © Copyright Clinical and Experimental Rheumatology 2022. |
| اللغة: |
English |
| URL الوصول: |
https://explore.openaire.eu/search/publication?articleId=od______2127::fe4d21b51cb56c3695696b1e9267a755
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:3219364 |
| Rights: |
OPEN |
| رقم الانضمام: |
edsair.od......2127..fe4d21b51cb56c3695696b1e9267a755 |
| قاعدة البيانات: |
OpenAIRE |