Amino acid metabolism, transport and signalling in the liver revisited
| العنوان: | Amino acid metabolism, transport and signalling in the liver revisited |
|---|---|
| المصدر: | Biochemical Pharmacology. 201 |
| بيانات النشر: | Elsevier Science, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | NITROGEN-METABOLISM, DIGITONIN COLLAGENASE PERFUSION, Amino acid transport, SPLANCHNIC BED UTILIZATION, Gluconeogenesis, RAT-LIVER, Amino acid signalling, Liver, SYSTEM-A, GLUTAMINE-SYNTHETASE, HEPATOCELLULAR-CARCINOMA, SKELETAL-MUSCLE, Hepatocyte, MESSENGER-RNA, Metabolic zonation, mTORC1, GENE-EXPRESSION |
| الوصف: | The liver controls the systemic exposure of amino acids entering via the gastro-intestinal tract. For most amino acids except branched chain amino acids, hepatic uptake is very efficient. This implies that the liver orchestrates amino acid metabolism and also controls systemic amino acid exposure. Although many amino acid transporters have been identified, cloned and investigated with respect to substrate specificity, transport mechanism, and zonal distribution, which of these players are involved in hepatocellular amino acid transport remains unclear. Here, we aim to provide a review of current insight into the molecular machinery of hepatic amino acid transport. Furthermore, we place this information in a comprehensive overview of amino acid transport, signalling and metabolism. |
| اللغة: | English |
| تدمد: | 1873-2968 0006-2952 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=od________83::bee9af1d1cfc1beb558d46c864298de1 https://cris.maastrichtuniversity.nl/en/publications/e8114ef6-51c7-43f5-94af-43a0fbe93e76 |
| رقم الانضمام: | edsair.od........83..bee9af1d1cfc1beb558d46c864298de1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18732968 00062952 |
|---|