β-Amyloid PET and 123I-FP-CIT SPECT in Mild Cognitive Impairment at Risk for Lewy Body Dementia
| العنوان: | β-Amyloid PET and 123I-FP-CIT SPECT in Mild Cognitive Impairment at Risk for Lewy Body Dementia |
|---|---|
| المؤلفون: | Val J. Lowe, Toji Miyagawa, Walter K. Kremers, Hoon Ki Min, Jeffrey L. Gunter, Julie A. Fields, Clifford R. Jack, Qin Chen, Ronald C. Petersen, Jonathan Graff-Radford, Kejal Kantarci, Christopher G. Schwarz, Rodolfo Savica, Bradley F. Boeve, David S. Knopman, Scott A. Przybelski, Tanis J. Ferman, Neill R. Graff-Radford, David T.W. Jones, Timothy G. Lesnick, Matthew L. Senjem |
| المصدر: | Neurology article-version (Version of Record) 3 |
| بيانات النشر: | Lippincott Williams & Wilkins, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Standardized uptake value, Gastroenterology, REM sleep behavior disorder, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, mental disorders, medicine, Dementia, Dopamine transporter, biology, Lewy body, business.industry, Dementia with Lewy bodies, Putamen, medicine.disease, 030104 developmental biology, chemistry, biology.protein, Neurology (clinical), Pittsburgh compound B, business, 030217 neurology & neurosurgery |
| الوصف: | ObjectiveTo determine the clinical phenotypes associated with the β-amyloid PET and dopamine transporter imaging (123I-FP-CIT SPECT) findings in mild cognitive impairment (MCI) with the core clinical features of dementia with Lewy bodies (DLB; MCI-LB).MethodsPatients with MCI who had at least 1 core clinical feature of DLB (n = 34) were grouped into β-amyloid A+ or A− and 123I-FP-CIT SPECT D+ or D− groups based on previously established abnormality cut points for A+ with Pittsburgh compound B PET standardized uptake value ratio (PiB SUVR) ≥1.48 and D+ with putamen z score with DaTQUANT 123I-FP-CIT SPECT. Individual patients with MCI-LB fell into 1 of 4 groups: A+D+, A+D−, A−D+, or A−D−. Log-transformed PiB SUVR and putamen z score were tested for associations with patient characteristics.ResultsThe A−D+ biomarker profile was most common (38.2%), followed by A+D+ (26.5%) and A−D− (26.5%). The least common was the A+D- biomarker profile (8.8%). The A+ group was older, had a higher frequency of APOE ε4 carriers, and had a lower Mini-Mental State Examination score than the A− group. The D+ group was more likely to have probable REM sleep behavior disorder. Lower putamen DaTQUANT z scores and lower PiB SUVRs were independently associated with higher Unified Parkinson’s Disease Rating Scale-III scores.ConclusionsA majority of patients with MCI-LB are characterized by low β-amyloid deposition and reduced dopaminergic activity. β-Amyloid PET and 123I-FP-CIT SPECT are complementary in characterizing clinical phenotypes of patients with MCI-LB. |
| اللغة: | English |
| تدمد: | 1526-632X 0028-3878 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbf87c208ce83c5845df815231ca4ed http://europepmc.org/articles/PMC8055344 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ffbf87c208ce83c5845df815231ca4ed |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1526632X 00283878 |
|---|