Multicellularity in animals: The potential for within-organism conflict
| العنوان: | Multicellularity in animals: The potential for within-organism conflict |
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| المؤلفون: | Jack Howe, Jochen C. Rink, Bo Wang, Ashleigh S. Griffin |
| المصدر: | Howe, J, Rink, J C, Wang, B & Griffin, A S 2022, ' Multicellularity in animals : The potential for within-organism conflict ', PNAS, vol. 119, no. 32, e2120457119 . https://doi.org/10.1073/pnas.2120457119 Proceedings of the National Academy of Sciences of the USA |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Multidisciplinary, Insecta, Reproduction, evolution, Animals, Cell Lineage, multicellularity, development, Biological Evolution, Clone Cells, Developmental Biology |
| الوصف: | Metazoans function as individual organisms but also as “colonies” of cells whose single-celled ancestors lived and reproduced independently. Insights from evolutionary biology about multicellular group formation help us understand the behavior of cells: why they cooperate, and why cooperation sometimes breaks down. Current explanations for multicellularity focus on two aspects of development which promote cooperation and limit conflict among cells: a single-cell bottleneck, which creates organisms composed of clones, and a separation of somatic and germ cell lineages, which reduces the selective advantage of cheating. However, many obligately multicellular organisms thrive with neither, creating the potential for within-organism conflict. Here, we argue that the prevalence of such organisms throughout the Metazoa requires us to refine our preconceptions of conflict-free multicellularity. Evolutionary theory must incorporate developmental mechanisms across a broad range of organisms—such as unusual reproductive strategies, totipotency, and cell competition—while developmental biology must incorporate evolutionary principles. To facilitate this cross-disciplinary approach, we provide a conceptual overview from evolutionary biology for developmental biologists, using analogous examples in the well-studied social insects. |
| وصف الملف: | application/pdf |
| تدمد: | 1091-6490 |
| DOI: | 10.1073/pnas.2120457119 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffbf468a79489baf009ea8d8d988a8c7 https://pubmed.ncbi.nlm.nih.gov/35862435 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ffbf468a79489baf009ea8d8d988a8c7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 |
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| DOI: | 10.1073/pnas.2120457119 |