Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation
| العنوان: | Associations between white matter microstructure and amyloid burden in preclinical Alzheimer's disease: A multimodal imaging investigation |
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| المؤلفون: | Barbara B. Bendlin, N. Maritza Dowling, Bradley T. Christian, Alex C. Birdsill, Cynthia M. Carlsson, Catherine L. Gallagher, Annie M. Racine, Dhanabalan Murali, Andrew L. Alexander, Jennifer M. Oh, Todd E. Barnhart, Nagesh Adluru, Howard A. Rowley, Sterling C. Johnson, Ozioma C. Okonkwo, Mark A. Sager, Caitlin A. Cleary, Sanjay Asthana, Ansel T. Hillmer |
| المصدر: | NeuroImage : Clinical NeuroImage: Clinical, Vol 4, Iss C, Pp 604-614 (2014) |
| بيانات النشر: | Elsevier, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | FSL, FMRIB Software Library, RAVLT, Rey Auditory Verbal Learning Test, Male, Pathology, Dr, radial diffusivity, ICBM, International Consortium for Brain Mapping, WASI, Wechsler Abbreviated Scale of Intelligence, Corpus callosum, Multimodal Imaging, lcsh:RC346-429, chemistry.chemical_compound, Cingulum–CC, cingulum adjacent to corpus callosum, Cognitive decline, FA, fractional anisotropy, PRELUDE, phase region expanding labeler for unwrapping discrete estimates, APOE4, apolipoprotein E gene ε4, Da, axial diffusivity, White matter, TMT, Trail Making Test, Brain, Alzheimer's disease, Middle Aged, DVR, distribution volume ratio, Molecular Imaging, medicine.anatomical_structure, Diffusion Tensor Imaging, Neurology, lcsh:R858-859.7, Female, Psychology, medicine.medical_specialty, Amyloid, Cognitive Neuroscience, Aβi, amyloid indeterminate, ANTs, Advanced Normalization Tools, DTI, Diffusion Tensor Imaging, BET, Brain Extraction Tool, FWE, family wise error, AD risk, lcsh:Computer applications to medicine. Medical informatics, Sensitivity and Specificity, Article, Amyloid imaging, FUGUE, FMRIB's utility for geometrically unwarping EPIs, Alzheimer Disease, Fractional anisotropy, mental disorders, medicine, WRAP, Wisconsin Registry for Alzheimer's Prevention, DTI-TK, Diffusion Tensor Imaging Toolkit, Humans, Radiology, Nuclear Medicine and imaging, WM, white matter, lcsh:Neurology. Diseases of the nervous system, Aged, MD, mean diffusivity, HARDI, high angular resolution diffusion imaging, ANCOVA, Analysis of Covariance, Amyloid beta-Peptides, Cingulum–HC, hippocampal cingulum (projecting to medial temporal lobe), Aβ−, amyloid negative, SPM, Statistical Parametric Mapping, Reproducibility of Results, PIB, Pittsburgh compound B, medicine.disease, PCC, posterior cingulate cortex, chemistry, nervous system, Positron-Emission Tomography, Aβ+, amyloid positive, GM, gray matter, Neurology (clinical), Pittsburgh compound B, WRAT, Wide Range Achievement Test, Diffusion MRI, FH, (parental) family history |
| الوصف: | Some cognitively healthy individuals develop brain amyloid accumulation, suggestive of incipient Alzheimer's disease (AD), but the effect of amyloid on other potentially informative imaging modalities, such as Diffusion Tensor Imaging (DTI), in characterizing brain changes in preclinical AD requires further exploration. In this study, a sample (N = 139, mean age 60.6, range 46 to 71) from the Wisconsin Registry for Alzheimer's Prevention (WRAP), a cohort enriched for AD risk factors, was recruited for a multimodal imaging investigation that included DTI and [C-11]Pittsburgh Compound B (PiB) positron emission tomography (PET). Participants were grouped as amyloid positive (Aβ+), amyloid indeterminate (Aβi), or amyloid negative (Aβ−) based on the amount and pattern of amyloid deposition. Regional voxel-wise analyses of four DTI metrics, fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (Da), and radial diffusivity (Dr), were performed based on amyloid grouping. Three regions of interest (ROIs), the cingulum adjacent to the corpus callosum, hippocampal cingulum, and lateral fornix, were selected based on their involvement in the early stages of AD. Voxel-wise analysis revealed higher FA among Aβ+ compared to Aβ− in all three ROIs and in Aβi compared to Aβ− in the cingulum adjacent to the corpus callosum. Follow-up exploratory whole-brain analyses were consistent with the ROI findings, revealing multiple regions where higher FA was associated with greater amyloid. Lower fronto-lateral gray matter MD was associated with higher amyloid burden. Further investigation showed a negative correlation between MD and PiB signal, suggesting that Aβ accumulation impairs diffusion. Interestingly, these findings in a largely presymptomatic sample are in contradistinction to relationships reported in the literature in symptomatic disease stages of Mild Cognitive Impairment and AD, which usually show higher MD and lower FA. Together with analyses showing that cognitive function in these participants is not associated with any of the four DTI metrics, the present results suggest an early relationship between PiB and DTI, which may be a meaningful indicator of the initiating or compensatory mechanisms of AD prior to cognitive decline. Graphical abstract Highlights • Study cohort of preclinical subjects (N = 139) at risk for Alzheimer's disease • Examination of four DTI metrics in three groups based on global amyloid load • Greater amyloid load was associated with higher fractional anisotropy. • Diffusivity was negatively associated with amyloid in fronto-lateral gray matter. • DTI metrics were not correlated with cognition at this early disease stage. |
| اللغة: | English |
| تدمد: | 2213-1582 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb112da2942dacb1d969f1eab88230a http://europepmc.org/articles/PMC4053642 |
| Rights: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ffb112da2942dacb1d969f1eab88230a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22131582 |
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